Table 1.

Univariate analysis of the effect of polymorphisms in folate-related genes on in vitro MTX sensitivity (TSI50) of childhood ALL

Univariate analysis
TSI50,cont, μM
TSI50,short, μM
Polymorphism
n
Median [IQR]
n
Median [IQR]
MTHFR 677C > T     
CC   47   0.071 [0.041-0.195]   68   0.562 [0.156-4.978]  
CT   31   0.063 [0.038-0.155]   39   0.540 [0.156-3.500]  
TT   8   0.090 [0.037-0.168]   13   1.481 [1.037-3.250]  
MTHFR 1298A > C     
AA   36   0.052 [0.030-0.124]   51   0.600 [0.156-1.488]  
AC   36   0.107 [0.055-0.225]†  49   0.904 [0.156-8.656]‡ 
CC   14   0.082 [0.034-0.194]   20   0.479 [0.156-3.449]  
MTR 2756 A > G     
AA   54   0.103 [0.035-0.180]   77   0.600 [0.156-6.059]  
AG   26   0.052 [0.038-0.117]   36   0.661 [0.156-1.795]  
GG   6   0.098 [0.056-0.204]   7   0.906 [0.156-1.460]  
MTRR 66A > G     
AA   23   0.054 [0.038-0.088]   29   0.156 [0.156-0.560]  
AG   37   0.104 [0.038-0.191]§  54   1.260 [0.169-7.658]∥ 
GG   26   0.112 [0.038-0.190]  36   0.984 [0.156-4.802]‡ 
MTHFD1 1958G > A     
GG   26   0.120 [0.033-0.196]   35   0.830 [0.156-2.840]  
GA   48   0.065 [0.041-0.164]   67   0.762 [0.156-5.310]  
AA   12   0.053 [0.036-0.174]   18   0.560 [0.156-2.653]  
SHMT1 1420 C > T     
CC   49   0.063 [0.037-0.161]   74   0.661 [0.156-4.096]  
CT   30   0.067 [0.037-0.182]   35   0.600 [0.156-3.500]  
TT   7   0.133 [0.088-0.235]   11   1.131 [0.410-5.614]  
TS 2R3R     
3R3R   25   0.059 [0.039-0.192]   42   0.951 [0.156-5.255]  
3R2R   42   0.069 [0.035-0.132]   52   0.398 [0.156-2.963]  
2R2R   19   0.151 [0.050-0.181]   25   1.042 [0.178-5.384]  
RFC 80G > A     
GG   30   0.058 [0.034-0.173]   43   0.580 [0.156-1.858]  
GA   43   0.071 [0.036-0.188]   54   0.508 [0.156-3.620]  
AA
 		 12
 		 0.080 [0.044-0.163]
 		 20
 		 1.110 [0.190-9.315]
 
Univariate analysis
TSI50,cont, μM
TSI50,short, μM
Polymorphism
n
Median [IQR]
n
Median [IQR]
MTHFR 677C > T     
CC   47   0.071 [0.041-0.195]   68   0.562 [0.156-4.978]  
CT   31   0.063 [0.038-0.155]   39   0.540 [0.156-3.500]  
TT   8   0.090 [0.037-0.168]   13   1.481 [1.037-3.250]  
MTHFR 1298A > C     
AA   36   0.052 [0.030-0.124]   51   0.600 [0.156-1.488]  
AC   36   0.107 [0.055-0.225]†  49   0.904 [0.156-8.656]‡ 
CC   14   0.082 [0.034-0.194]   20   0.479 [0.156-3.449]  
MTR 2756 A > G     
AA   54   0.103 [0.035-0.180]   77   0.600 [0.156-6.059]  
AG   26   0.052 [0.038-0.117]   36   0.661 [0.156-1.795]  
GG   6   0.098 [0.056-0.204]   7   0.906 [0.156-1.460]  
MTRR 66A > G     
AA   23   0.054 [0.038-0.088]   29   0.156 [0.156-0.560]  
AG   37   0.104 [0.038-0.191]§  54   1.260 [0.169-7.658]∥ 
GG   26   0.112 [0.038-0.190]  36   0.984 [0.156-4.802]‡ 
MTHFD1 1958G > A     
GG   26   0.120 [0.033-0.196]   35   0.830 [0.156-2.840]  
GA   48   0.065 [0.041-0.164]   67   0.762 [0.156-5.310]  
AA   12   0.053 [0.036-0.174]   18   0.560 [0.156-2.653]  
SHMT1 1420 C > T     
CC   49   0.063 [0.037-0.161]   74   0.661 [0.156-4.096]  
CT   30   0.067 [0.037-0.182]   35   0.600 [0.156-3.500]  
TT   7   0.133 [0.088-0.235]   11   1.131 [0.410-5.614]  
TS 2R3R     
3R3R   25   0.059 [0.039-0.192]   42   0.951 [0.156-5.255]  
3R2R   42   0.069 [0.035-0.132]   52   0.398 [0.156-2.963]  
2R2R   19   0.151 [0.050-0.181]   25   1.042 [0.178-5.384]  
RFC 80G > A     
GG   30   0.058 [0.034-0.173]   43   0.580 [0.156-1.858]  
GA   43   0.071 [0.036-0.188]   54   0.508 [0.156-3.620]  
AA
 		 12
 		 0.080 [0.044-0.163]
 		 20
 		 1.110 [0.190-9.315]
 

IQR indicates interquartile range.

†

P < .01.

‡

P < .05.

§

P = .08.

∥

P < .001.

P = .09.

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