Conjugation of a CD4+ HTLV-1-infected cell line with CD4+ cell lines with and without LFA-1
. | Odds ratio*of MTOC polarization in MS9 versus Jβ2.7 cells* . | χ2 (DF = 6) . | P† . |
|---|---|---|---|
| Jβ2.7/ΔLFA-1 | 2.50 | 45.8 | <.001 |
| Jβ2.7/wtLFA-1 | 1.83 | 25.8 | <.001 |
| Jβ2.7/mock | 0.85 | 15.3 | .018 |
. | Odds ratio*of MTOC polarization in MS9 versus Jβ2.7 cells* . | χ2 (DF = 6) . | P† . |
|---|---|---|---|
| Jβ2.7/ΔLFA-1 | 2.50 | 45.8 | <.001 |
| Jβ2.7/wtLFA-1 | 1.83 | 25.8 | <.001 |
| Jβ2.7/mock | 0.85 | 15.3 | .018 |
Three independent experiments were performed with the CD4+ cell lines. Conjugates were formed between the HTLV-1- infected cell line MS9 and the Jβ2.7 cell lines. Where 2 cells formed a conjugate, the orientation of the MTOC was noted, and the odds ratio was calculated for polarization of the MTOC in the infected MS9 cells versus the uninfected Jβ2.7 cells.
Summary (weighted mean) odds ratio from the 3 experiments
Significance level of odds ratio