Polarization of the MTOC in CD4+ T-cell lines
Monoclonal antibody . | No. experiments . | Polarization in Jurkat/MS9 cells, % . | Odds ratio*of MTOC polarization in MS9 vs Jurkat cells . | χ2 (DF) . | P† . |
|---|---|---|---|---|---|
| Anti-CD3 | 2 | 89/15 | 0.02 | 147.0 (4) | < .001 |
| Anti-CD54 | 4 | 31/68 | 3.97 | 24.5 (8) | .002 |
| Anti-CD11a | 4 | 40/55 | 1.68 | 37.0 (8) | < .001 |
| Anti-CD58 | 1 | 25/30 | 1.25 | 0.63 (1) | .427 |
| Anti-CD28 | 2 | 69/29 | 0.17 | 75.0 (4) | < .001 |
| Anti-CD18 | 2 | 71/43 | 0.27 | 53.8 (4) | < .001 |
| Anti-CD2 | 1 | 32/54 | 2.49 | 9.87 (1) | .002 |
| Anti-CD50 | 1 | 72/69 | 0.87 | 0.21 (1) | .642 |
| Anti-CD25 | 1 | 7/58 | 18.40 | 59.3 (1) | < .001 |
Monoclonal antibody . | No. experiments . | Polarization in Jurkat/MS9 cells, % . | Odds ratio*of MTOC polarization in MS9 vs Jurkat cells . | χ2 (DF) . | P† . |
|---|---|---|---|---|---|
| Anti-CD3 | 2 | 89/15 | 0.02 | 147.0 (4) | < .001 |
| Anti-CD54 | 4 | 31/68 | 3.97 | 24.5 (8) | .002 |
| Anti-CD11a | 4 | 40/55 | 1.68 | 37.0 (8) | < .001 |
| Anti-CD58 | 1 | 25/30 | 1.25 | 0.63 (1) | .427 |
| Anti-CD28 | 2 | 69/29 | 0.17 | 75.0 (4) | < .001 |
| Anti-CD18 | 2 | 71/43 | 0.27 | 53.8 (4) | < .001 |
| Anti-CD2 | 1 | 32/54 | 2.49 | 9.87 (1) | .002 |
| Anti-CD50 | 1 | 72/69 | 0.87 | 0.21 (1) | .642 |
| Anti-CD25 | 1 | 7/58 | 18.40 | 59.3 (1) | < .001 |
The CD4+ HTLV-1-infected cell line, MS9, or uninfected Jurkat cells were mixed with antibody-coated beads. Polarization of the MTOC toward the beads was observed, and the odds ratios were calculated when comparing polarization in MS9 versus Jurkat cells.
Summary (weighted mean) odds ratio from indicated number of experiments
Significance level of odds ratio