Interaction between HTLV-1 infection and cross-linking of cell-surface molecules in causing polarization of the microtubule cytoskeleton
Cross-linking antibody . | No. experiments . | Odds ratio*of MTOC polarization in Gag p19+ cells vs Gag p19- cells . | Polarization in Gag p19+ cells, % . | χ2 (DF) . | P† . |
|---|---|---|---|---|---|
| Anti-CD54 (ICAM-1) | 8 | 2.58 | 56 | 166 (16) | < .001 |
| Anti-CD25 (IL-2Rα) | 3 | 2.18 | 47 | 34 (6) | < .001 |
| Anti-CD11a (LFA-1) | 8 | 1.14 | 70 | 42 (16) | < .001 |
| Anti-CD3 (TCR complex) | 3 | 0.84 | 63 | 17 (6) | .009 |
| Anti-CD28 (costimulatory) | 3 | 0.66 | 61 | 18 (6) | .006 |
Cross-linking antibody . | No. experiments . | Odds ratio*of MTOC polarization in Gag p19+ cells vs Gag p19- cells . | Polarization in Gag p19+ cells, % . | χ2 (DF) . | P† . |
|---|---|---|---|---|---|
| Anti-CD54 (ICAM-1) | 8 | 2.58 | 56 | 166 (16) | < .001 |
| Anti-CD25 (IL-2Rα) | 3 | 2.18 | 47 | 34 (6) | < .001 |
| Anti-CD11a (LFA-1) | 8 | 1.14 | 70 | 42 (16) | < .001 |
| Anti-CD3 (TCR complex) | 3 | 0.84 | 63 | 17 (6) | .009 |
| Anti-CD28 (costimulatory) | 3 | 0.66 | 61 | 18 (6) | .006 |
Latex beads were coated with monoclonal antibodies to the respective T-cell surface molecule and incubated for 1 to 2 hours with PBMCs from individuals infected with HTLV-1. An odds ratio (OR) less than 1 indicates that HTLV-1 infection and cross-linking were synergistic in inducing MTOC polarization; OR greater than 1 indicates that HTLV-1 infection inhibited the antibody-induced polarization. TCR indicates T-cell receptor.
Summary (weighted mean) odds ratio from indicated number of experiments
Significance level of odds ratio