SIRs for familial history of NHL by histopathologic type
. | Any first-degree relative . | . | Parents only . | . | Siblings only . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Histopathologic type in offspring . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | |||
| NHL | 115 | 1.8 (1.5-2.2)* | 89 | 1.8 (1.4-2.2)* | 26 | 1.9 (1.1-3.2)* | |||
| Diffuse large B-cell | 15 | 1.8 (1.0-3.0) | 15 | 2.3 (1.2-3.8)* | 0 | — | |||
| Follicular | 29 | 2.0 (1.4-2.9)* | 22 | 2.0 (0.9-3.0) | 7 | 2.3 (1.1-4.8)* | |||
| B-cell, NOS | 19 | 1.8 (1.1-2.8)* | 11 | 1.3 (0.7-2.4) | 8 | 3.4 (1.5-6.8)* | |||
| T-cell | 5 | 1.0 (0.3-2.3) | 4 | 1.0 (0.3-2.6) | 1 | 1.0 (0-5.5) | |||
| NHL, NOS | 22 | 1.7 (1.1-2.6)* | 18 | 1.8 (1.1-2.8)* | 4 | 1.4 (0.4-3.6) | |||
| Other | 25 | 2.1 (1.4-3.1)* | 19 | 2.1 (1.2-3.2)* | 6 | 2.4 (0.8-5.3) | |||
| Multiple myeloma | 13 | 0.7 (0.4-1.2) | 8 | 0.5 (0.2-1.1) | 4 | 0.9 (0.2-2.4) | |||
| Plasma cell | 12 | 0.7 (0.3-1.2) | 7 | 0.5 (0.2-1.0) | 4 | 1.0 (0.3-2.5) | |||
| Plasmacytoma, NOS | 1 | 0.8 (0-4.8) | 1 | 1.1 (0-6.1) | 0 | — | |||
| CLL | 25 | 1.7 (1.1-2.5)* | 20 | 1.7 (1.0-2.7) | 5 | 1.5 (0.5-3.5) | |||
. | Any first-degree relative . | . | Parents only . | . | Siblings only . | . | |||
|---|---|---|---|---|---|---|---|---|---|
| Histopathologic type in offspring . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | O . | SIR (95% CI) . | |||
| NHL | 115 | 1.8 (1.5-2.2)* | 89 | 1.8 (1.4-2.2)* | 26 | 1.9 (1.1-3.2)* | |||
| Diffuse large B-cell | 15 | 1.8 (1.0-3.0) | 15 | 2.3 (1.2-3.8)* | 0 | — | |||
| Follicular | 29 | 2.0 (1.4-2.9)* | 22 | 2.0 (0.9-3.0) | 7 | 2.3 (1.1-4.8)* | |||
| B-cell, NOS | 19 | 1.8 (1.1-2.8)* | 11 | 1.3 (0.7-2.4) | 8 | 3.4 (1.5-6.8)* | |||
| T-cell | 5 | 1.0 (0.3-2.3) | 4 | 1.0 (0.3-2.6) | 1 | 1.0 (0-5.5) | |||
| NHL, NOS | 22 | 1.7 (1.1-2.6)* | 18 | 1.8 (1.1-2.8)* | 4 | 1.4 (0.4-3.6) | |||
| Other | 25 | 2.1 (1.4-3.1)* | 19 | 2.1 (1.2-3.2)* | 6 | 2.4 (0.8-5.3) | |||
| Multiple myeloma | 13 | 0.7 (0.4-1.2) | 8 | 0.5 (0.2-1.1) | 4 | 0.9 (0.2-2.4) | |||
| Plasma cell | 12 | 0.7 (0.3-1.2) | 7 | 0.5 (0.2-1.0) | 4 | 1.0 (0.3-2.5) | |||
| Plasmacytoma, NOS | 1 | 0.8 (0-4.8) | 1 | 1.1 (0-6.1) | 0 | — | |||
| CLL | 25 | 1.7 (1.1-2.5)* | 20 | 1.7 (1.0-2.7) | 5 | 1.5 (0.5-3.5) | |||
First-degree relatives are parents, siblings, and offspring.
O indicates number of observed cases; CLL indicates chronic lymphocytic leukemia; and—, not determined.
95% CI does not include 1.00.