Weights of the livers and the kidneys and iron concentrations in rats
. | Vehicle . | E2, 0.1 mg/kg . | E2, 1 mg/kg . |
|---|---|---|---|
| Weight, g | |||
| Liver | |||
| Basal Diet | 5.8 ± 0.7 | 6.5 ± 0.7 | 7.3 ± 0.9* |
| Low-Iron Diet | 4.9 ± 0.6† | 5.6 ± 0.6*† | 7.2 ± 0.8* |
| Kidney | |||
| Basal Diet | 0.58 ± 0.03 | 0.58 ± 0.07 | 0.65 ± 0.06* |
| Low-Iron Diet | 0.60 ± 0.04 | 0.61 ± 0.05 | 0.67 ± 0.05* |
| Iron concentration, μg/g | |||
| Liver | |||
| Basal Diet | 330.3 ± 71.6 | 336.5 ± 90.1 | 310.6 ± 74.2 |
| Low-Iron Diet | 58.9 ± 18.6† | 65.2 ± 13.3† | 106.5 ± 51.7*† |
| Kidney | |||
| Basal Diet | 114.5 ± 28.0 | 125.4 ± 32.9 | 165.3 ± 40.1* |
| Low-Iron Diet | 63.4 ± 15.3† | 70.9 ± 9.0† | 75.1 ± 15.0† |
. | Vehicle . | E2, 0.1 mg/kg . | E2, 1 mg/kg . |
|---|---|---|---|
| Weight, g | |||
| Liver | |||
| Basal Diet | 5.8 ± 0.7 | 6.5 ± 0.7 | 7.3 ± 0.9* |
| Low-Iron Diet | 4.9 ± 0.6† | 5.6 ± 0.6*† | 7.2 ± 0.8* |
| Kidney | |||
| Basal Diet | 0.58 ± 0.03 | 0.58 ± 0.07 | 0.65 ± 0.06* |
| Low-Iron Diet | 0.60 ± 0.04 | 0.61 ± 0.05 | 0.67 ± 0.05* |
| Iron concentration, μg/g | |||
| Liver | |||
| Basal Diet | 330.3 ± 71.6 | 336.5 ± 90.1 | 310.6 ± 74.2 |
| Low-Iron Diet | 58.9 ± 18.6† | 65.2 ± 13.3† | 106.5 ± 51.7*† |
| Kidney | |||
| Basal Diet | 114.5 ± 28.0 | 125.4 ± 32.9 | 165.3 ± 40.1* |
| Low-Iron Diet | 63.4 ± 15.3† | 70.9 ± 9.0† | 75.1 ± 15.0† |
The rats were administered E2 at the indicated doses 3 times a week for 2 months and fed the Basal Diet 5755 (n = 8 for all groups) or the Low-Iron Purified Diet (vehicle and 0.1 mg/kg E2 groups, n = 9; 1 mg/kg E2 group, n = 8) from TestDiet. Samples were taken from the same rats as in Table 1. Data are presented by mean ± SD.
P < .05 (compared with vehicle group).
P < .05 (compared with Basal Diet group).