Table 1. MLL PTD and MLL WT expression... | American Society of Hematology

Table 1.

MLL PTD and MLL WT expression in primary AML with or without an MLL PTD gene rearrangement

UPN	MLL genotype status^*	MLL PTD	MLL WT
AMLs with normal karyotype andMLL PTD
211	PTD/WT	+	-
340	PTD/WT	+	-
300	PTD/WT	+	-
350	PTD/WT	+	+/-†
2166	PTD/WT	+	-
316	PTD/WT	+	-
1101	PTD/WT	+	-
102	PTD/WT	+	-
590	PTD/WT	+	-
758	PTD/WT	+	-
548	PTD/WT	+	-
176	PTD/WT	+	-
866	PTD/WT	+	-
203	PTD/WT	+	-
204	PTD/WT	+	-
146	PTD/WT	+	-
180	PTD/WT	+	-
AMLs with trisomy 11 andMLL PTD
108	PTD/WT/WT	+	-
023d	PTD/WT/WT	+	+
023r	PTD/WT/WT	+	-
AMLs with normal karyotype
155	WT/WT	-	+
156	WT/WT	-	+
157	WT/WT	-	+
168	WT/WT	-	+
178	WT/WT	-	+
179	WT/WT	-	+
183	WT/WT	-	+
003	WT/WT	-	+
111	WT/WT	-	+
010	WT/WT	-	+
8361	WT/WT	-	+
876	WT/WT	-	+

UPN	MLL genotype status^*	MLL PTD	MLL WT
AMLs with normal karyotype andMLL PTD
211	PTD/WT	+	-
340	PTD/WT	+	-
300	PTD/WT	+	-
350	PTD/WT	+	+/-†
2166	PTD/WT	+	-
316	PTD/WT	+	-
1101	PTD/WT	+	-
102	PTD/WT	+	-
590	PTD/WT	+	-
758	PTD/WT	+	-
548	PTD/WT	+	-
176	PTD/WT	+	-
866	PTD/WT	+	-
203	PTD/WT	+	-
204	PTD/WT	+	-
146	PTD/WT	+	-
180	PTD/WT	+	-
AMLs with trisomy 11 andMLL PTD
108	PTD/WT/WT	+	-
023d	PTD/WT/WT	+	+
023r	PTD/WT/WT	+	-
AMLs with normal karyotype
155	WT/WT	-	+
156	WT/WT	-	+
157	WT/WT	-	+
168	WT/WT	-	+
178	WT/WT	-	+
179	WT/WT	-	+
183	WT/WT	-	+
003	WT/WT	-	+
111	WT/WT	-	+
010	WT/WT	-	+
8361	WT/WT	-	+
876	WT/WT	-	+

UPN indicates unique patient number; +, transcript present; -, transcript absent; +/-, low expression; d following UPN, condition at time of diagnosis; r following UPN, condition at time of relapse.

Genotype was previously characterized in these AML samples by semiquantitative Southern blotting and conventional nested RT-PCR sequencing

†

This patient had 32% blasts prior to enrichment

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