Effect of PLCβ2/β3 or P13Kγ knock-out in carotid injury model
. | Stable . | Unstable . | No clot . |
|---|---|---|---|
| PLCβ/β3+/+ | 10 | 2 | 0 |
| PLCβ2/β3-/- | 0 | 1 | 6 |
| P13Kγ+/+ | 12 | 2 | 0 |
| P13Kγ-/- | 0 | 3 | 5 |
. | Stable . | Unstable . | No clot . |
|---|---|---|---|
| PLCβ/β3+/+ | 10 | 2 | 0 |
| PLCβ2/β3-/- | 0 | 1 | 6 |
| P13Kγ+/+ | 12 | 2 | 0 |
| P13Kγ-/- | 0 | 3 | 5 |
Mice lacking either PLCβ2/β3 or P13Kγ were analyzed by a ferric chloride-induced carotid injury model. Results from multiple independent experiments are shown. These data demonstrate that loss of either PLCβ2/β3 or P13Kγ induces a defect that prevents stable arterial thrombus formation.