Haplotype analysis of SNP markers in KL, BMP6, and ANXA2
. | Control, % . | Case, % . |
|---|---|---|
| KL block 1 haplotype* | ||
| CACGAATTGT | 34 | 41 |
| CACGAGATAT | 14 | 21 |
| CACGGAATGT | 12 | 8 |
| AATAGGACAG | 7 | 11 |
| CACGAAATGT | 7 | 5 |
| CACGAATTAT | 3 | 2 |
| CACGAAATAT | 2 | 1 |
| CACGAGTTAT | 2 | 1 |
| CATAGAATGT | 2 | 1 |
| CACGGATTGT | 2 | 1 |
| Rare (< 1%) | 16 | 7 |
| KL block 2 haplotype* | ||
| CCATTC | 41 | 45 |
| ACGCCC | 27 | 32 |
| ATGCCC | 7 | 7 |
| CCATCC | 9 | 5 |
| CCATTT | 4 | 6 |
| ACGCTC | 7 | 3 |
| BMP6 haplotype* | ||
| CTTTCAC | 16 | 12 |
| CTTCCCC | 13 | 13 |
| CTTCCCT | 10 | 10 |
| CTTCTCT | 8 | 9 |
| TACCTCT | 7 | 7 |
| CTTTCCC | 6 | 7 |
| CTTCTCC | 5 | 8 |
| TACCTCC | 6 | 6 |
| CTCCCCC | 4 | 4 |
| TTCCTCT | 3 | 4 |
| CTTTCCT | 3 | 3 |
| TACTCCT | 3 | 2 |
| TACCCCC | 2 | 2 |
| TTCCTCC | 1 | 2 |
| TACCCCT | 1 | 2 |
| Rare (< 1%) | 9 | 9 |
| ANXA2 haplotype† | ||
| GACACG | 28 | 23 |
| TACGCA | 14 | 18 |
| TACACG | 14 | 14 |
| TGCGCG | 12 | 12 |
| TGGGCG | 11 | 9 |
| TGGGGG | 10 | 8 |
| TACGCG | 4 | 8 |
| TGGGCA | 2 | 2 |
| TACGGG | 1 | 3 |
| TGCGCA | 2 | 1 |
| Rare (< 1%) | 3 | 3 |
. | Control, % . | Case, % . |
|---|---|---|
| KL block 1 haplotype* | ||
| CACGAATTGT | 34 | 41 |
| CACGAGATAT | 14 | 21 |
| CACGGAATGT | 12 | 8 |
| AATAGGACAG | 7 | 11 |
| CACGAAATGT | 7 | 5 |
| CACGAATTAT | 3 | 2 |
| CACGAAATAT | 2 | 1 |
| CACGAGTTAT | 2 | 1 |
| CATAGAATGT | 2 | 1 |
| CACGGATTGT | 2 | 1 |
| Rare (< 1%) | 16 | 7 |
| KL block 2 haplotype* | ||
| CCATTC | 41 | 45 |
| ACGCCC | 27 | 32 |
| ATGCCC | 7 | 7 |
| CCATCC | 9 | 5 |
| CCATTT | 4 | 6 |
| ACGCTC | 7 | 3 |
| BMP6 haplotype* | ||
| CTTTCAC | 16 | 12 |
| CTTCCCC | 13 | 13 |
| CTTCCCT | 10 | 10 |
| CTTCTCT | 8 | 9 |
| TACCTCT | 7 | 7 |
| CTTTCCC | 6 | 7 |
| CTTCTCC | 5 | 8 |
| TACCTCC | 6 | 6 |
| CTCCCCC | 4 | 4 |
| TTCCTCT | 3 | 4 |
| CTTTCCT | 3 | 3 |
| TACTCCT | 3 | 2 |
| TACCCCC | 2 | 2 |
| TTCCTCC | 1 | 2 |
| TACCCCT | 1 | 2 |
| Rare (< 1%) | 9 | 9 |
| ANXA2 haplotype† | ||
| GACACG | 28 | 23 |
| TACGCA | 14 | 18 |
| TACACG | 14 | 14 |
| TGCGCG | 12 | 12 |
| TGGGCG | 11 | 9 |
| TGGGGG | 10 | 8 |
| TACGCG | 4 | 8 |
| TGGGCA | 2 | 2 |
| TACGGG | 1 | 3 |
| TGCGCA | 2 | 1 |
| Rare (< 1%) | 3 | 3 |
Haplotypes for KL block 1 are composed of SNPs rs576404, rs499091, rs2238166, rs211234, rs211239, rs565587, rs495764, rs516306, rs685417, and rs1334928. Haplotypes in KL block 2 are composed of SNPs rs656525, rs1888057, rs657049, rs497050, rs2249358, and rs560014. Haplotypes for BMP6 are composed of SNPs rs267192, rs267196, rs267201, rs408505, rs449853, rs1225934, and rs267170. Haplotypes for ANXA2 comprise SNPs rs1033028, rs7170178, hCV11770326, rs7163836, rs8037326, and hCV9036132.
P = .01, global
P = .03, global