Table 1.

SNPs associated with osteonecrosis

SNP no.
Gene
Genotype
AVN
Control
Reference genotype
AVN
Control
OR
95% CI
P
rs1019856* TGFBR2  AA   55   36   AG   143   156   1.75   1.08-2.86   .023  
rs934328† TGFBR2  CC   75   60   T_   137   242   2.36   1.56-3.51   < .001  
rs284157*† TGFBR3  A_   209   344   GG   174   65   4.95   3.53-6.94   < .001  
rs270393*† BMP6  GG   63   39   C_   211   226   1.80   1.15-2.81   .009  
rs267196† BMP6  TT   253   226   AT   78   116   1.85   1.30-2.63   .001  
rs267201 BMP6  CT   161   161   TT   92   142   1.60   1.13-2.28   .008  
rs449853† BMP6  TT   71   47   C_   308   338   1.68   1.12-2.52   .012  
rs1225934† BMP6  CC   308   265   AC   70   123   1.96   1.41-2.78   .001  
rs212527† ECE1  GG   75   22   A_   123   196   5.68   3.33-9.62   < .001  
rs5369*† EDN1  AG   48   41   GG   57   128   3.04   1.76-5.24   .001  
hCV7464888† EDN1  AG   49   61   AA   209   141   2.22   1.41-3.45   .001  
rs979091* ERG  CC   39   13   AA   9   12   3.85   1.32-11.10   .014  
rs2836430  ERG  AA   373   353   AC   33   59   1.96   1.22-3.13   .005  
rs7163836  ANXA2  GG   149   119   AA   44   70   1.82   1.15-2.86   .010  
hCV11770326† ANXA2  CC   227   204   G_   55   138   3.38   2.28-4.97   < .001  
rs7170178† ANXA2  AA   164   140   G   148   210   1.98   1.44-2.72   < .001  
rs1033028† ANXA2  T_   368   368   GG   14   36   2.43   1.28-4.57   .007  
hCV26910500† ANXA2  G_   156   122   AA   102   166   2.56   1.79-3.68   < .001  
hCV1571628  ANXA2  TT   124   138   AT   111   179   1.45   1.03-2.08   .034  
rs538874† STARD13  G_   286   331   AA   37   51   1.79   1.12-2.85   .015  
rs475303 STARD13  CT   132   93   CC   278   279   1.42   1.04-1.96   .029  
rs648464† STARD13  AG   193   126   GG   155   185   1.91   1.39-2.61   .001  
rs480780*† KL  AC   69   44   CC   6   5   2.97   1.83-4.84   .001  
rs211235† KL  C_   150   194   AA   9   46   3.97   1.81-8.69   .001  
rs2149860† KL  G_   290   231   AA   134   148   1.42   1.05-1.90   .021  
rs685417† KL  AG   199   133   GG   155   164   1.66   1.21-2.28   .002  
rs516306† KL  T_   411   365   CC   8   19   2.86   1.19-6.90   .019  
rs565587† KL  AG   142   113   AA   130   172   1.80   1.28-2.53   .001  
rs211239† KL  A_   388   314   GG   27   53   2.58   1.56-4.28   .001  
rs211234† KL  G_   402   333   AA   8   24   4.08   1.73-9.62   .001  
rs2238166  KL  C_   408   360   TT   8   16   2.50   1.02-6.16   .046  
rs499091† KL  A_   368   335   GG   8   19   2.85   1.18-6.89   .020  
rs576404† KL  C_   411   372   AA   5   16   4.23   1.40-12.82   .010  
hCV3118898† APRIN  C_   396   333   AA   26   53   2.51   1.51-4.14   .001  
hCV11710292
 		APRIN
 		 AG
 		 174
 		 125
 		 AA
 		 225
 		 232
 		 1.45
 		 1.08-1.95
 		 .014
 
SNP no.
Gene
Genotype
AVN
Control
Reference genotype
AVN
Control
OR
95% CI
P
rs1019856* TGFBR2  AA   55   36   AG   143   156   1.75   1.08-2.86   .023  
rs934328† TGFBR2  CC   75   60   T_   137   242   2.36   1.56-3.51   < .001  
rs284157*† TGFBR3  A_   209   344   GG   174   65   4.95   3.53-6.94   < .001  
rs270393*† BMP6  GG   63   39   C_   211   226   1.80   1.15-2.81   .009  
rs267196† BMP6  TT   253   226   AT   78   116   1.85   1.30-2.63   .001  
rs267201 BMP6  CT   161   161   TT   92   142   1.60   1.13-2.28   .008  
rs449853† BMP6  TT   71   47   C_   308   338   1.68   1.12-2.52   .012  
rs1225934† BMP6  CC   308   265   AC   70   123   1.96   1.41-2.78   .001  
rs212527† ECE1  GG   75   22   A_   123   196   5.68   3.33-9.62   < .001  
rs5369*† EDN1  AG   48   41   GG   57   128   3.04   1.76-5.24   .001  
hCV7464888† EDN1  AG   49   61   AA   209   141   2.22   1.41-3.45   .001  
rs979091* ERG  CC   39   13   AA   9   12   3.85   1.32-11.10   .014  
rs2836430  ERG  AA   373   353   AC   33   59   1.96   1.22-3.13   .005  
rs7163836  ANXA2  GG   149   119   AA   44   70   1.82   1.15-2.86   .010  
hCV11770326† ANXA2  CC   227   204   G_   55   138   3.38   2.28-4.97   < .001  
rs7170178† ANXA2  AA   164   140   G   148   210   1.98   1.44-2.72   < .001  
rs1033028† ANXA2  T_   368   368   GG   14   36   2.43   1.28-4.57   .007  
hCV26910500† ANXA2  G_   156   122   AA   102   166   2.56   1.79-3.68   < .001  
hCV1571628  ANXA2  TT   124   138   AT   111   179   1.45   1.03-2.08   .034  
rs538874† STARD13  G_   286   331   AA   37   51   1.79   1.12-2.85   .015  
rs475303 STARD13  CT   132   93   CC   278   279   1.42   1.04-1.96   .029  
rs648464† STARD13  AG   193   126   GG   155   185   1.91   1.39-2.61   .001  
rs480780*† KL  AC   69   44   CC   6   5   2.97   1.83-4.84   .001  
rs211235† KL  C_   150   194   AA   9   46   3.97   1.81-8.69   .001  
rs2149860† KL  G_   290   231   AA   134   148   1.42   1.05-1.90   .021  
rs685417† KL  AG   199   133   GG   155   164   1.66   1.21-2.28   .002  
rs516306† KL  T_   411   365   CC   8   19   2.86   1.19-6.90   .019  
rs565587† KL  AG   142   113   AA   130   172   1.80   1.28-2.53   .001  
rs211239† KL  A_   388   314   GG   27   53   2.58   1.56-4.28   .001  
rs211234† KL  G_   402   333   AA   8   24   4.08   1.73-9.62   .001  
rs2238166  KL  C_   408   360   TT   8   16   2.50   1.02-6.16   .046  
rs499091† KL  A_   368   335   GG   8   19   2.85   1.18-6.89   .020  
rs576404† KL  C_   411   372   AA   5   16   4.23   1.40-12.82   .010  
hCV3118898† APRIN  C_   396   333   AA   26   53   2.51   1.51-4.14   .001  
hCV11710292
 		APRIN
 		 AG
 		 174
 		 125
 		 AA
 		 225
 		 232
 		 1.45
 		 1.08-1.95
 		 .014
 

The selection of individual genotypes was based on 512 tests, so that the largest P value to accept a significant association with 20% FDR is .0016. The selection of pooled genotypes was based on 233 tests so that the largest P value to accept a significant association with 20% FDR was .0309. The STARD13 and APRIN genes flank the KL gene.

*

SNPs that were typed as part of the first, low-density SNP screen for the candidate genes

†

SNPs that are significant, with 20% FDR

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