Table 1.

Clinical features of patients at diagnosis, as assessed by WB




No.

%
Total   94   100  
Mean age, y (range)   56 (34-77)   NA  
Female   38   40.4  
Mean BM PCs, % (range)   47 (5-99)   NA  
M component   
IgG   53   56.4  
IgA   22   23.4  
Light chain   17   18.1  
Nonsecretory   2   2.1  
K   60   65.2  
Mean Hb level, g/dL (range)   11 (5.6-16)   NA  
Bone lytic lesions   
0   26   27.6  
1 or more   68   72.3  
Salmon and Durie stage   
I   4   4.2  
II   27   28.7  
III   63   67.0  
Mean creatinine level, mg/dL (range)   2 (0.4-8.4)   NA  
Del13q*  18   50.0  
Mean 2-microglobulin level, g/L (range)  5 (1.1-22.8)   NA  
First-line treatment   
Conventional   28   29.8  
Thalidomide plus conventional   4   4.2  
Autologous or allogeneic SCT
 
62
 
66.0
 



No.

%
Total   94   100  
Mean age, y (range)   56 (34-77)   NA  
Female   38   40.4  
Mean BM PCs, % (range)   47 (5-99)   NA  
M component   
IgG   53   56.4  
IgA   22   23.4  
Light chain   17   18.1  
Nonsecretory   2   2.1  
K   60   65.2  
Mean Hb level, g/dL (range)   11 (5.6-16)   NA  
Bone lytic lesions   
0   26   27.6  
1 or more   68   72.3  
Salmon and Durie stage   
I   4   4.2  
II   27   28.7  
III   63   67.0  
Mean creatinine level, mg/dL (range)   2 (0.4-8.4)   NA  
Del13q*  18   50.0  
Mean 2-microglobulin level, g/L (range)  5 (1.1-22.8)   NA  
First-line treatment   
Conventional   28   29.8  
Thalidomide plus conventional   4   4.2  
Autologous or allogeneic SCT
 
62
 
66.0
 

WB indicates Western blotting; NA, not applicable; BM, bone marrow; PCs, plasma cells; Hb, hemoglobin; SCT, stem cell transplantation.

*

Assessed by fluorescence in situ hybridization, available in 36 patients.

β2-microglobulin available in 77 patients.

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