Activation of downstream BCR signaling pathways by imm-IgM in CLL with mutated and unmutated Ig VH genes
VH gene mutational status . | ERK . | Akt . | PLCγ2 . | NF-κB . | JNK . | p38 MAPK . |
|---|---|---|---|---|---|---|
| Unmutated VH CLL, positive/total no. cases (%) | 11/11 (100)* | 11/11 (100) | 9/10 (90) | 8/11 (73) | 6/10 (60) | 6/11 (55) |
| Mutated VH CLL, positive/total no. cases (%) | 9/9 (100) | 10/10 (100) | 4/6 (67) | 5/10 (50) | 2/9 (22) | 6/9 (66) |
VH gene mutational status . | ERK . | Akt . | PLCγ2 . | NF-κB . | JNK . | p38 MAPK . |
|---|---|---|---|---|---|---|
| Unmutated VH CLL, positive/total no. cases (%) | 11/11 (100)* | 11/11 (100) | 9/10 (90) | 8/11 (73) | 6/10 (60) | 6/11 (55) |
| Mutated VH CLL, positive/total no. cases (%) | 9/9 (100) | 10/10 (100) | 4/6 (67) | 5/10 (50) | 2/9 (22) | 6/9 (66) |
Number and percentage of positive cases.