Activation of downstream BCR signaling pathways by sol-IgM in CLL with mutated and unmutated Ig VH genes
VH gene mutational status . | ERK . | Akt . | PLCγ2 . | NF-κB . | JNK . | p38 MAPK . |
|---|---|---|---|---|---|---|
| Unmutated VH CLL, positive/total no. cases (%) | 16/16 (100)* | 16/16 (100) | 12/14 (86) | 7/15 (47) | 2/15 (13) | 2/15 (13) |
| Mutated VH CLL, positive/total no. cases (%) | 18/24 (75) | 18/24 (75) | 10/20 (50) | 3/23 (13) | 1/16 (6) | 2/15 (13) |
VH gene mutational status . | ERK . | Akt . | PLCγ2 . | NF-κB . | JNK . | p38 MAPK . |
|---|---|---|---|---|---|---|
| Unmutated VH CLL, positive/total no. cases (%) | 16/16 (100)* | 16/16 (100) | 12/14 (86) | 7/15 (47) | 2/15 (13) | 2/15 (13) |
| Mutated VH CLL, positive/total no. cases (%) | 18/24 (75) | 18/24 (75) | 10/20 (50) | 3/23 (13) | 1/16 (6) | 2/15 (13) |
Number and percentage of positive cases.