Levels of sVCAM-1 and SDF-1α in BM and PB before and after G-CSF+FL mobilization
. | sVCAM-1 . | . | SDF-1α . | . | ||
|---|---|---|---|---|---|---|
| Mice . | PB, ng/mL . | BM, ng/femur . | PB, pg/mL . | BM, pg/femur . | ||
| Wild type before G + FL | 701.4 ± 61.1 [3] | 6.8 ± 0.6 [3] | 476.2 ± 121.9 [3] | 862.8 ± 134.4 [3] | ||
| Wild type after G + FL | 1176.0* ± 56.4 [3] | 3.4* ± 0.2 [3] | <250.0 ± 0.0 [3] | 480.1 ± 3.8 [3] | ||
| VCAM-1f/f before G + FL | 766.1 ± 12.7 [3] | 15.5 ± 1.1 [3] | 638.0 ± 131.6 [3] | 772.1 ± 101.4 [3] | ||
| VCAM-1f/f after G + FL | 836.6 ± 81.9 [7] | 4.2† ± 0.4 [5] | 807.8 ± 286.6 [4] | 353.2† ± 43.7 [6] | ||
| VCAM-1Δ/Δ before G + FL | 181.4* ± 52.5 [2] | 2.6* ± 0.6 [2] | 846.9 ± 120.4 [3] | 1056.0 ± 35.0 [3] | ||
| VCAM-1Δ/Δ after G + FL | 205.4‡ ± 11.1 [8] | 0.9‡ ± 0.1 [4] | 462.0 ± 121.9 [5] | 414.2§ ± 50.8 [9] | ||
. | sVCAM-1 . | . | SDF-1α . | . | ||
|---|---|---|---|---|---|---|
| Mice . | PB, ng/mL . | BM, ng/femur . | PB, pg/mL . | BM, pg/femur . | ||
| Wild type before G + FL | 701.4 ± 61.1 [3] | 6.8 ± 0.6 [3] | 476.2 ± 121.9 [3] | 862.8 ± 134.4 [3] | ||
| Wild type after G + FL | 1176.0* ± 56.4 [3] | 3.4* ± 0.2 [3] | <250.0 ± 0.0 [3] | 480.1 ± 3.8 [3] | ||
| VCAM-1f/f before G + FL | 766.1 ± 12.7 [3] | 15.5 ± 1.1 [3] | 638.0 ± 131.6 [3] | 772.1 ± 101.4 [3] | ||
| VCAM-1f/f after G + FL | 836.6 ± 81.9 [7] | 4.2† ± 0.4 [5] | 807.8 ± 286.6 [4] | 353.2† ± 43.7 [6] | ||
| VCAM-1Δ/Δ before G + FL | 181.4* ± 52.5 [2] | 2.6* ± 0.6 [2] | 846.9 ± 120.4 [3] | 1056.0 ± 35.0 [3] | ||
| VCAM-1Δ/Δ after G + FL | 205.4‡ ± 11.1 [8] | 0.9‡ ± 0.1 [4] | 462.0 ± 121.9 [5] | 414.2§ ± 50.8 [9] | ||
Values shown are the mean ± SEM with the number of mice shown in brackets.
Differs from untreated f/f mice at P < .05 and P < .005 in blood and marrow, respectively.
Significant changes after treatment: P < .005.
Differs from treated f/f mice at P < .0005 and P < .001 in blood and marrow, respectively.
Significant changes after treatment: P < .000005.