Position and frequencies of VKORC1 genetic polymorphisms and SNPs used for haplotype construction
SNP gene location . | . | Frequency‡ . | . | . | ||
|---|---|---|---|---|---|---|
| Relative to A* . | Relative to first nucleotide† . | NCBI . | Our study . | Region . | ||
| -4931T>C | 381 | 0.47 | 0.42 | 5′ flanking | ||
| -4451C>A | 861 | 0.26 | 0.33 | 5′ flanking | ||
| -2659G>C | 2653 | 0.17 | 0.21 | 5′ flanking | ||
| -1877A>G | 3435 | 0.14 | 0.02 | 5′ flanking | ||
| -1639G>A | 3673 | 0.29 | 0.42 | 5′ flanking | ||
| 497T>G | 5808 | 0.18 | 0.30 | Intron 1 | ||
| 1173C>T | 6484 | 0.31 | 0.42 | Intron 1 | ||
SNP gene location . | . | Frequency‡ . | . | . | ||
|---|---|---|---|---|---|---|
| Relative to A* . | Relative to first nucleotide† . | NCBI . | Our study . | Region . | ||
| -4931T>C | 381 | 0.47 | 0.42 | 5′ flanking | ||
| -4451C>A | 861 | 0.26 | 0.33 | 5′ flanking | ||
| -2659G>C | 2653 | 0.17 | 0.21 | 5′ flanking | ||
| -1877A>G | 3435 | 0.14 | 0.02 | 5′ flanking | ||
| -1639G>A | 3673 | 0.29 | 0.42 | 5′ flanking | ||
| 497T>G | 5808 | 0.18 | 0.30 | Intron 1 | ||
| 1173C>T | 6484 | 0.31 | 0.42 | Intron 1 | ||
The position of the SNP is relative to the A of the ATG initiation codon (denoted nucleotide + 1).
Designation of the SNP relative to the first nucleotide referred to as accession number AY587020 (National Center for Biotechnology Information [NCBI]) or in http://pga.gs.washington.edu/data/vkorc1/welcome.html. The length of the analyzed VKORC1 sequence (including 5′ flanking, exonic, intronic, and 3′ untranslated regions) is of 12 megabases (Mb), and the bases are numbered from 1 to 12 000.
The indicated frequencies correspond to those of the minor allele.