Distribution of CLL cases with mutated VH genes, by sample site and sequence homology
. | Bone marrow, no. cases . | Blood, no. cases . | Lymph node, no. cases . | Spleen, no. cases . | Total, no. cases . |
|---|---|---|---|---|---|
| Sequence homology 95%-98% | 19 | 24 | 12 | 2 | 57 |
| Sequence homology less than 95% | 22 | 44 | 2 | 0 | 68 |
| All cases | 41 | 68 | 14 | 2 | 125 |
. | Bone marrow, no. cases . | Blood, no. cases . | Lymph node, no. cases . | Spleen, no. cases . | Total, no. cases . |
|---|---|---|---|---|---|
| Sequence homology 95%-98% | 19 | 24 | 12 | 2 | 57 |
| Sequence homology less than 95% | 22 | 44 | 2 | 0 | 68 |
| All cases | 41 | 68 | 14 | 2 | 125 |
CLL cases with mutated VH genes were divided at 95% sequence homology (the median frequency of homology to germline for the mutated cases) with regard to sample site. The data show a significant difference between groups (P = .002, Pearson Chi-square). Lymph node/spleen samples demonstrated a lower mutation frequency than bone marrow/blood samples.