Patient characteristics at diagnosis
. | Phase of disease . | . | . | . | ||
|---|---|---|---|---|---|---|
. | CR1 . | CR2/3 . | Relapse . | Total . | ||
| Total no. patients | 17 | 7 | 16 | 40 | ||
| Patient age, mo, median (range) | 6.7 (3.8-11.2) | 10.2 (4.1-11.8) | 4.3 (0-11.2) | 6.6 | ||
| No. male/no. female patients | 6/11 | 3/4 | 7/9 | 16/24 | ||
| WBC, × 109/L, median (range) | 146 (4-1250) | 112 (50-364) | 139 (3-370) | 112 (3-1250) | ||
| Extramedullary disease, no. patients | ||||||
| Total | 3 | 3 | 5 | 11 | ||
| Site | ||||||
| CNS | 2 | 2 | 5 | 9 | ||
| Skin | 3 | 1 | 0 | 4 | ||
| Cytogenetics, no. patients | ||||||
| Normal | 1 | 3 | 2 | 6 | ||
| MLL+ and 11q23 abnormalities | 14 | 3 | 8 | 25 | ||
| Normal with MLL+ | 2 | 0 | 0 | 2* | ||
| Hypodiploid with MLL+ | 2 | 0 | 0 | 2† | ||
| t(4;11)(q21;q23) | 4 | 3 | 7 | 14 | ||
| t(11;19)(q23;p13) | 3 | 0 | 0 | 3 | ||
| t(9;11)(p22;q23) | 2 | 0 | 0 | 2 | ||
| t(1;11)(p32;q23) | 1 | 0 | 0 | 1 | ||
| t(2;11)(q12;q23) | 0 | 0 | 1 | 1 | ||
| Other abnormalities | ||||||
| Del(3) (q24), add (9)(p23) | 1 | 0 | 0 | 1 | ||
| t(1;22)(p13;q13) | 0 | 0 | 1 | 1 | ||
| Unknown | 1 | 1 | 5 | 7 | ||
. | Phase of disease . | . | . | . | ||
|---|---|---|---|---|---|---|
. | CR1 . | CR2/3 . | Relapse . | Total . | ||
| Total no. patients | 17 | 7 | 16 | 40 | ||
| Patient age, mo, median (range) | 6.7 (3.8-11.2) | 10.2 (4.1-11.8) | 4.3 (0-11.2) | 6.6 | ||
| No. male/no. female patients | 6/11 | 3/4 | 7/9 | 16/24 | ||
| WBC, × 109/L, median (range) | 146 (4-1250) | 112 (50-364) | 139 (3-370) | 112 (3-1250) | ||
| Extramedullary disease, no. patients | ||||||
| Total | 3 | 3 | 5 | 11 | ||
| Site | ||||||
| CNS | 2 | 2 | 5 | 9 | ||
| Skin | 3 | 1 | 0 | 4 | ||
| Cytogenetics, no. patients | ||||||
| Normal | 1 | 3 | 2 | 6 | ||
| MLL+ and 11q23 abnormalities | 14 | 3 | 8 | 25 | ||
| Normal with MLL+ | 2 | 0 | 0 | 2* | ||
| Hypodiploid with MLL+ | 2 | 0 | 0 | 2† | ||
| t(4;11)(q21;q23) | 4 | 3 | 7 | 14 | ||
| t(11;19)(q23;p13) | 3 | 0 | 0 | 3 | ||
| t(9;11)(p22;q23) | 2 | 0 | 0 | 2 | ||
| t(1;11)(p32;q23) | 1 | 0 | 0 | 1 | ||
| t(2;11)(q12;q23) | 0 | 0 | 1 | 1 | ||
| Other abnormalities | ||||||
| Del(3) (q24), add (9)(p23) | 1 | 0 | 0 | 1 | ||
| t(1;22)(p13;q13) | 0 | 0 | 1 | 1 | ||
| Unknown | 1 | 1 | 5 | 7 | ||
CR1 indicates first complete remission; CR2/3, second/third complete remission; WBC, white blood cell count; CNS, central nervous system.
Two patients were documented to have rearrangement of MLL gene by FISH analysis with otherwise normal cytogenetics
Two patients were found to have 42 to 45 chromosomes and were also found to be MLL gene rearrangement positive