Colony-forming cell content of spleens following bone marrow transplantation
. | . | Colonies per recipient spleen . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor . | Recipient spleen cellularity, × 10-5 . | Blast . | G . | GM . | M . | Eo . | Meg . | |||||
| Mpl+/+c-Myb+/+ | 321 ± 134 | 116 ± 329 | 122 ± 344 | 0 | 159 ± 345 | 0 | 456 ± 430 | |||||
| Mpl+/+c-MybPlt4/Plt4 | 27 ± 14 | 44 ± 56 | 467 ± 441 | 358 ± 433 | 640 ± 941 | 0 | 5 457 ± 9 385 | |||||
| Mpl-/-c-Myb+/+ | 292 ± 173 | 62 ± 197 | 1270 ± 1436 | 863 ± 1250 | 1074 ± 1253 | 0 | 1 772 ± 2 244 | |||||
| Mpl-/-c-MybPlt4/Plt4 | 73 ± 78 | 80 ± 178 | 2895 ± 3233 | 1572 ± 1006 | 2362 ± 1571 | 0 | 22 150 ± 30 122* | |||||
. | . | Colonies per recipient spleen . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Donor . | Recipient spleen cellularity, × 10-5 . | Blast . | G . | GM . | M . | Eo . | Meg . | |||||
| Mpl+/+c-Myb+/+ | 321 ± 134 | 116 ± 329 | 122 ± 344 | 0 | 159 ± 345 | 0 | 456 ± 430 | |||||
| Mpl+/+c-MybPlt4/Plt4 | 27 ± 14 | 44 ± 56 | 467 ± 441 | 358 ± 433 | 640 ± 941 | 0 | 5 457 ± 9 385 | |||||
| Mpl-/-c-Myb+/+ | 292 ± 173 | 62 ± 197 | 1270 ± 1436 | 863 ± 1250 | 1074 ± 1253 | 0 | 1 772 ± 2 244 | |||||
| Mpl-/-c-MybPlt4/Plt4 | 73 ± 78 | 80 ± 178 | 2895 ± 3233 | 1572 ± 1006 | 2362 ± 1571 | 0 | 22 150 ± 30 122* | |||||
Mean values ± standard deviations of calculated total colony-forming cells per recipient spleen. Two to 3 donor mice of each genotype were used to perform transplantation in 4 to 5 recipients each.
G indicates granulocyte; GM, granulocyte-macrophage; M, macrophage; Eo, eosinophil, Meg, megakaryocyte.
P < .05 for comparison with data from Mpl-/-c-Myb+/+ mice