Inhibition by anti-LFA-1 antibody of autologous or allogeneic anti-third-party CTL-induced apoptosis of B-CLL cells
. | Experiment . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | |||||
| B-CLL | 13.4 | 6.2 | 9.3 | 12.5 | 21.0 | 9.0 | |||||
| B-CLL + autologous CTL | 36.00 | 46.20 | 38.60 | — | — | — | |||||
| B-CLL + autologous CTL + anti-LFA-1 | 20.30 | 25.00 | 27.00 | — | — | — | |||||
| B-CLL + allogeneic CTL | — | — | — | 41 | 54 | 37.18 | |||||
| B-CLL + allogeneic CTL + anti-LFA-1 | — | — | — | 23 | 29 | 23.55 | |||||
| % inhibition* | 66.81 | 84.13 | 39.19 | 63.16 | 75.76 | 48.37 | |||||
. | Experiment . | . | . | . | . | . | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
. | 1 . | 2 . | 3 . | 4 . | 5 . | 6 . | |||||
| B-CLL | 13.4 | 6.2 | 9.3 | 12.5 | 21.0 | 9.0 | |||||
| B-CLL + autologous CTL | 36.00 | 46.20 | 38.60 | — | — | — | |||||
| B-CLL + autologous CTL + anti-LFA-1 | 20.30 | 25.00 | 27.00 | — | — | — | |||||
| B-CLL + allogeneic CTL | — | — | — | 41 | 54 | 37.18 | |||||
| B-CLL + allogeneic CTL + anti-LFA-1 | — | — | — | 23 | 29 | 23.55 | |||||
| % inhibition* | 66.81 | 84.13 | 39.19 | 63.16 | 75.76 | 48.37 | |||||
— indicates no data.
This value was calculated as follows: (B-CLL + allogeneic or autologous CTL + anti-LFA-1/B-CLL + allogeneic CTL) × 100.