Predictive factors of clinical and molecular CR after CHOP
. | Univariate . | . | Multivariate by logistic analysis . | . | ||
|---|---|---|---|---|---|---|
| Factors . | No. CR/no. total (%) . | P, χ2 . | OR (95% CI) . | P . | ||
| Sex | .46 | 0.80 (0.16-4.17) | .79 | |||
| Male | 14/48 (29) | |||||
| Female | 6/28 (21) | |||||
| Age | .77 | 2.85 (0.23-35.25) | .41 | |||
| 60 y or younger | 17/66 (26) | |||||
| Older than 60 y | 3/10 (30) | |||||
| LDH* | .67 | 1.35 (0.11-16.47) | ||||
| Yes | 3/9 (33) | |||||
| No | 17/64 (27) | |||||
| Bulky disease† | .018 | NA | NA | |||
| Yes | 0/13 (0) | |||||
| No | 20/63 (32) | |||||
| BM infiltration (histology) | .009 | 0.32 (0.06-1.63) | .17 | |||
| Yes | 9/52 (17) | |||||
| No | 11/24 (46) | |||||
| Clinical stage | .023 | 0.49 (0.02-9.53) | .63 | |||
| Below III | 3/4 (75) | |||||
| III or higher | 17/72 (24) | |||||
| RQ-PCR on BM at diagnosis‡ | <.001 | 11.46 (2.66-49.3) | .001 | |||
| High | 0/19 (0) | |||||
| Intermediate | 3/26 (11) | |||||
| Low | 17/31 (55) | |||||
. | Univariate . | . | Multivariate by logistic analysis . | . | ||
|---|---|---|---|---|---|---|
| Factors . | No. CR/no. total (%) . | P, χ2 . | OR (95% CI) . | P . | ||
| Sex | .46 | 0.80 (0.16-4.17) | .79 | |||
| Male | 14/48 (29) | |||||
| Female | 6/28 (21) | |||||
| Age | .77 | 2.85 (0.23-35.25) | .41 | |||
| 60 y or younger | 17/66 (26) | |||||
| Older than 60 y | 3/10 (30) | |||||
| LDH* | .67 | 1.35 (0.11-16.47) | ||||
| Yes | 3/9 (33) | |||||
| No | 17/64 (27) | |||||
| Bulky disease† | .018 | NA | NA | |||
| Yes | 0/13 (0) | |||||
| No | 20/63 (32) | |||||
| BM infiltration (histology) | .009 | 0.32 (0.06-1.63) | .17 | |||
| Yes | 9/52 (17) | |||||
| No | 11/24 (46) | |||||
| Clinical stage | .023 | 0.49 (0.02-9.53) | .63 | |||
| Below III | 3/4 (75) | |||||
| III or higher | 17/72 (24) | |||||
| RQ-PCR on BM at diagnosis‡ | <.001 | 11.46 (2.66-49.3) | .001 | |||
| High | 0/19 (0) | |||||
| Intermediate | 3/26 (11) | |||||
| Low | 17/31 (55) | |||||
Seventy-six patients (BM sample available at diagnosis) were eligible for univariate and multivariate analysis. Data on 60 patients were analyzed for the multivariate analysis.
NA indicates not applicable.
The LDH value was not available at diagnosis in 3 patients
The presence of bulky disease (13 patients) was automatically dropped from the multivariate analysis model because it perfectly predicts the failure of CR achievement
The numbers of BCL2/IgH+ cells in the BM were defined as being high, when more than one positive cell was detected among 100 normal cells; intermediate, when 1 positive cell was detected among 100 to 1000 normal cells; or low, when 1 positive cell in was detected among 1000 to 100 000 normal cells