Higher than 1.3-fold change in at least 66% of the 6 MCL patients identified 77 proteins
Protein . | Corresponding gene . | Molecular function . |
|---|---|---|
| RCC1 (regulator of chromosome condensation) | CHC1 | DNA binding, Ran guanyl-nucleotide exchange factor activity |
| p43/EMAPII (endothelial monocyte-activating polypeptide II) precursor | SCYE1 | Chemotaxis, cell-cell signaling, inflammatory response |
| Inhibitor 2 | PPP1R2 | Type 1 serine/threonine-specific protein phosphatase inhibitor activity |
| AKAP149 (A-kinase anchor protein 149) | AKAP1 | Protein kinase A anchoring activity |
| CHD3 (chromodomain helicase DNA binding protein 3) | CHD3 | ATP-dependent DNA helicase activity, ATP binding |
| PP5 (protein phosphatase 5) | PPP5C | Protein phosphatase type 2C activity, involved in p53 and Hsp90 regulation |
| Caspase-7/Mch3 (modifier of chinchilla 3) | CASP7 | Apoptosis |
| Hsp10 (heat shock protein 10) | HSPE1 | Protein folding, chaperone protein |
| SH2B (Src-homology-3) | SH2B | Growth factor, cytokine, and immunoreceptor signaling |
| MDM2 (murine double minute 2) | MDM2 | Negative regulation of cell proliferation, oncogenesis |
| Hsp90 (heat shock protein 90) | HSPCA | Protein folding, chaperone protein |
| PKA c (protein kinase A) | PRKACA | Protein-tyrosine kinase activity |
| CRIK (citron Rho-interacting kinase) | CIT | Small GTPase regulatory/interacting protein activity |
| Per2 (period circadian protein 2) | PER2 | Regulator of circadian expression of VEGF mRNA in hypoxic tumors |
| Neurexin I | NRXNI | Receptor activity |
| Crk (Proto-oncogene C-Crk) | CRK | Adaptor in tyrosine kinase signal transduction |
| CDC25C (M-phase inducer phosphatase 3) | CDC25C | Prenylated protein tyrosine phosphatase activity |
| CPG16/CaM kinase VI (calcium calmodulin dependent kinase CPG16) | DCAMKL1 | Protein serine/threonine kinase activity |
| G3BP (Ras-GTPase-activating protein binding protein 1) | G3BP | Ras protein signal transduction |
| CDC34 (ubiquitin-conjugating enzyme E2-32 kDa complementing) | CDC34 | Ubiquitin-protein ligase activity |
| BRUCE (baculoviral IAP repeat-containing 6) | BIRC6 | Cysteine protease inhibitor activity, ubiquitin conjugating enzyme activity, apoptosis inhibitor activity |
| p73a (p73 alpha) | TP73 | Transcription factor activity |
| PKC i (protein kinase C i) | PRKCI | Atypical protein kinase C activity |
| Neurotensin receptor 3 | NT | Induces migration |
| La protein (Sjogren syndrome antigen B) | SSB | Ribonuclear protein complex |
| Rag-1 (V(D)J recombination activating protein 1) | RAG1 | Endonuclease activity, DNA binding |
| Cadherin-5 | CDH5 | Calcium ion binding, cell adhesion molecule activity |
| FADD (Fas-associating protein with death domain) | FADD | Induction of apoptosis |
| TBP (TATA box-binding protein) | TBP | DNA binding, RNA polymerase II transcription factor activity |
| Maspin | SERPINB5 | Serine protease inhibitor activity |
| CTBP2 (C-terminal binding protein 2) | CTBP2 | 2-Hacid DH; oxidoreductase activity |
| Calnexin | CANX | Calcium ion binding, chaperone activity |
| SMRT (silencing mediator of retinoic and thyroid hormone receptors) | NCOR2 | Myb_DNA-binding |
| MST3 (serine/threonine-protein kinase 3) | MST3 | Apoptosis regulation |
| FBP (fructose 1,6-bisphosphate) | FUBP1 | Transcription factor activity |
| Mena (enabled protein homolog) | ENAH | Regulation of cell motility and adhesion |
| Rap 2 (Ras-related protein Rap-2) | RAP2B | RAS small monomeric GTPase activity |
| Topoisomerase II a | TOP2A | DNA metabolism |
| PYK2 (pyruvate kinase 2) | PTK2B | Protein tyrosine kinase activity |
| Pericentrin | PCNT2 | Structural constituent of cytoskeleton |
| Karyopherin b | KPNB1 | Zinc ion binding, protein transporter activity |
| eIF-4g (eukaryotic translation initiation factor 4 gamma) | EIF4G1 | Translation factor activity |
| Erp72 (protein disulfide-isomerase A4 precursor) | ERp72 | Endoplasmic reticulum protein, chaperone protein |
| Neurogenin 3 | NEUROG1 | Transcription factor |
| IkBa/MAD-3 (NF-kappaB inhibitor alpha) | NFKB1A | Transcription factor binding |
| GSK-3B (Glycogen synthase kinase-3 beta) | GSK3B | Regulates atypical PKC regulation of cell polarity, apoptosis |
| DNA topoisomerase II b | TOP2B | DNA topoisomerase type II activity |
| MCM6 (DNA replication licensing factor MCM6) | MCM6 | DNA binding, DNA dependent ATPase activity |
| Nexilin | Nexilin | Actin binding protein |
| KIF3B (kinesin-like protein KIF3B) | KIF3B | Kinase, microtubule motor activity |
| PTPIC (protein-tyrosine phosphatase, non-receptor type 6) | PTPN6 | Protein tyrosine phosphatase activity |
| PTEN/MMAC1 (phosphatase and tensin homolog deleted on chromosome 10) | PTEN | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein tyrosine phosphatase activity |
| JAM1 (junctional adhesion molecule 1 precursor) | JAM1 | Intracellular junction |
| DP103/Gemin3 (probable ATP-dependent RNA helicase DDX20) | DDX20 | DNA binding, ATP-dependent RNA helicase activity |
| Sam68 (substrate of Src in mitosis) | SAM68 | Transcription, RNA splicing, cell cycle regulation |
| NABC1 (breast carcinoma amplified sequence 1) | NABC1 | Ion transporting protein |
| GRB14 (growth factor receptor-bound protein 14) | GRB14 | SH3/SH2 adaptor protein activity |
| MLH1 (MutL homolog 1) | MLH1 | ATP binding |
| GM130 (Golgi matrix protein of 130 kDa) | GOLGA2 | Peripheral membrane protein associated with the Golgi bodies |
| mEPHX (microsomal epoxide hydrolase) | EPHX1 | Epoxide hydrolase activity |
| b-tubulin | TUBB | Structural constituent of cytoskeleton |
| JAK 1 (Janus kinase 1) | JAK1 | Protein-tyrosine kinase activity |
| SMAC (second mitochondria-derived activator of caspases)/DIABLO (Diablo homolog, mitochondrial precursor) | SMAC | Apoptosis |
| IGFBP-3 (insulin-like growth factor binding protein 3 precursor) | IGBP3 | Insulin-like growth factor binding |
| 14-3-3e | 14-3-3 | Apoptosis |
| DP-1 (Dodeca-satellite-binding protein 1) | TFDP1 | Transcription factor activity, cell cycle regulation |
| Cyclin D1 | CCND1 | Cell cycle regulation |
| FYB (FYN-binding protein)/SLAP-130 (Src-like adaptor protein 130) | SLAP130 | SLP76-associated phosphoprotein |
| SRPK1 (SFRS protein kinase 1) | SRPK1 | Protein serine threonine kinase activity |
| Kalinin B1 | LAMB3 | Cell laminin |
| L1 (deferiprone) | L1CAM | Cell adhesion |
| XCCR4 (X-ray repair complementing defective repair in Chinese hamster cells 4) | XCCR4 | X-ray repair |
| P54nrb (54 kDa nuclear RNA-and DNA-binding protein) | P54NRB | Nuclear RNA binding protein |
| PKA R1 (cAMP-dependent protein kinase type I regulatory subunit) | PRKAR1B | c-AMP-dependent protein kinase |
| Carboxypeptidase E | CPE | Metallopeptidase activity, hydrolase activity, carboxypeptidase activity |
| MST1 (hepatocyte growth factor-like protein precursor) | MST1 | Serine threonine kinase |
| PTP1D/SHP2 (Protein-tyrosine phosphatase, non-receptor type 11) | PTP1D | PI3K signaling pathway |
Protein . | Corresponding gene . | Molecular function . |
|---|---|---|
| RCC1 (regulator of chromosome condensation) | CHC1 | DNA binding, Ran guanyl-nucleotide exchange factor activity |
| p43/EMAPII (endothelial monocyte-activating polypeptide II) precursor | SCYE1 | Chemotaxis, cell-cell signaling, inflammatory response |
| Inhibitor 2 | PPP1R2 | Type 1 serine/threonine-specific protein phosphatase inhibitor activity |
| AKAP149 (A-kinase anchor protein 149) | AKAP1 | Protein kinase A anchoring activity |
| CHD3 (chromodomain helicase DNA binding protein 3) | CHD3 | ATP-dependent DNA helicase activity, ATP binding |
| PP5 (protein phosphatase 5) | PPP5C | Protein phosphatase type 2C activity, involved in p53 and Hsp90 regulation |
| Caspase-7/Mch3 (modifier of chinchilla 3) | CASP7 | Apoptosis |
| Hsp10 (heat shock protein 10) | HSPE1 | Protein folding, chaperone protein |
| SH2B (Src-homology-3) | SH2B | Growth factor, cytokine, and immunoreceptor signaling |
| MDM2 (murine double minute 2) | MDM2 | Negative regulation of cell proliferation, oncogenesis |
| Hsp90 (heat shock protein 90) | HSPCA | Protein folding, chaperone protein |
| PKA c (protein kinase A) | PRKACA | Protein-tyrosine kinase activity |
| CRIK (citron Rho-interacting kinase) | CIT | Small GTPase regulatory/interacting protein activity |
| Per2 (period circadian protein 2) | PER2 | Regulator of circadian expression of VEGF mRNA in hypoxic tumors |
| Neurexin I | NRXNI | Receptor activity |
| Crk (Proto-oncogene C-Crk) | CRK | Adaptor in tyrosine kinase signal transduction |
| CDC25C (M-phase inducer phosphatase 3) | CDC25C | Prenylated protein tyrosine phosphatase activity |
| CPG16/CaM kinase VI (calcium calmodulin dependent kinase CPG16) | DCAMKL1 | Protein serine/threonine kinase activity |
| G3BP (Ras-GTPase-activating protein binding protein 1) | G3BP | Ras protein signal transduction |
| CDC34 (ubiquitin-conjugating enzyme E2-32 kDa complementing) | CDC34 | Ubiquitin-protein ligase activity |
| BRUCE (baculoviral IAP repeat-containing 6) | BIRC6 | Cysteine protease inhibitor activity, ubiquitin conjugating enzyme activity, apoptosis inhibitor activity |
| p73a (p73 alpha) | TP73 | Transcription factor activity |
| PKC i (protein kinase C i) | PRKCI | Atypical protein kinase C activity |
| Neurotensin receptor 3 | NT | Induces migration |
| La protein (Sjogren syndrome antigen B) | SSB | Ribonuclear protein complex |
| Rag-1 (V(D)J recombination activating protein 1) | RAG1 | Endonuclease activity, DNA binding |
| Cadherin-5 | CDH5 | Calcium ion binding, cell adhesion molecule activity |
| FADD (Fas-associating protein with death domain) | FADD | Induction of apoptosis |
| TBP (TATA box-binding protein) | TBP | DNA binding, RNA polymerase II transcription factor activity |
| Maspin | SERPINB5 | Serine protease inhibitor activity |
| CTBP2 (C-terminal binding protein 2) | CTBP2 | 2-Hacid DH; oxidoreductase activity |
| Calnexin | CANX | Calcium ion binding, chaperone activity |
| SMRT (silencing mediator of retinoic and thyroid hormone receptors) | NCOR2 | Myb_DNA-binding |
| MST3 (serine/threonine-protein kinase 3) | MST3 | Apoptosis regulation |
| FBP (fructose 1,6-bisphosphate) | FUBP1 | Transcription factor activity |
| Mena (enabled protein homolog) | ENAH | Regulation of cell motility and adhesion |
| Rap 2 (Ras-related protein Rap-2) | RAP2B | RAS small monomeric GTPase activity |
| Topoisomerase II a | TOP2A | DNA metabolism |
| PYK2 (pyruvate kinase 2) | PTK2B | Protein tyrosine kinase activity |
| Pericentrin | PCNT2 | Structural constituent of cytoskeleton |
| Karyopherin b | KPNB1 | Zinc ion binding, protein transporter activity |
| eIF-4g (eukaryotic translation initiation factor 4 gamma) | EIF4G1 | Translation factor activity |
| Erp72 (protein disulfide-isomerase A4 precursor) | ERp72 | Endoplasmic reticulum protein, chaperone protein |
| Neurogenin 3 | NEUROG1 | Transcription factor |
| IkBa/MAD-3 (NF-kappaB inhibitor alpha) | NFKB1A | Transcription factor binding |
| GSK-3B (Glycogen synthase kinase-3 beta) | GSK3B | Regulates atypical PKC regulation of cell polarity, apoptosis |
| DNA topoisomerase II b | TOP2B | DNA topoisomerase type II activity |
| MCM6 (DNA replication licensing factor MCM6) | MCM6 | DNA binding, DNA dependent ATPase activity |
| Nexilin | Nexilin | Actin binding protein |
| KIF3B (kinesin-like protein KIF3B) | KIF3B | Kinase, microtubule motor activity |
| PTPIC (protein-tyrosine phosphatase, non-receptor type 6) | PTPN6 | Protein tyrosine phosphatase activity |
| PTEN/MMAC1 (phosphatase and tensin homolog deleted on chromosome 10) | PTEN | Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein tyrosine phosphatase activity |
| JAM1 (junctional adhesion molecule 1 precursor) | JAM1 | Intracellular junction |
| DP103/Gemin3 (probable ATP-dependent RNA helicase DDX20) | DDX20 | DNA binding, ATP-dependent RNA helicase activity |
| Sam68 (substrate of Src in mitosis) | SAM68 | Transcription, RNA splicing, cell cycle regulation |
| NABC1 (breast carcinoma amplified sequence 1) | NABC1 | Ion transporting protein |
| GRB14 (growth factor receptor-bound protein 14) | GRB14 | SH3/SH2 adaptor protein activity |
| MLH1 (MutL homolog 1) | MLH1 | ATP binding |
| GM130 (Golgi matrix protein of 130 kDa) | GOLGA2 | Peripheral membrane protein associated with the Golgi bodies |
| mEPHX (microsomal epoxide hydrolase) | EPHX1 | Epoxide hydrolase activity |
| b-tubulin | TUBB | Structural constituent of cytoskeleton |
| JAK 1 (Janus kinase 1) | JAK1 | Protein-tyrosine kinase activity |
| SMAC (second mitochondria-derived activator of caspases)/DIABLO (Diablo homolog, mitochondrial precursor) | SMAC | Apoptosis |
| IGFBP-3 (insulin-like growth factor binding protein 3 precursor) | IGBP3 | Insulin-like growth factor binding |
| 14-3-3e | 14-3-3 | Apoptosis |
| DP-1 (Dodeca-satellite-binding protein 1) | TFDP1 | Transcription factor activity, cell cycle regulation |
| Cyclin D1 | CCND1 | Cell cycle regulation |
| FYB (FYN-binding protein)/SLAP-130 (Src-like adaptor protein 130) | SLAP130 | SLP76-associated phosphoprotein |
| SRPK1 (SFRS protein kinase 1) | SRPK1 | Protein serine threonine kinase activity |
| Kalinin B1 | LAMB3 | Cell laminin |
| L1 (deferiprone) | L1CAM | Cell adhesion |
| XCCR4 (X-ray repair complementing defective repair in Chinese hamster cells 4) | XCCR4 | X-ray repair |
| P54nrb (54 kDa nuclear RNA-and DNA-binding protein) | P54NRB | Nuclear RNA binding protein |
| PKA R1 (cAMP-dependent protein kinase type I regulatory subunit) | PRKAR1B | c-AMP-dependent protein kinase |
| Carboxypeptidase E | CPE | Metallopeptidase activity, hydrolase activity, carboxypeptidase activity |
| MST1 (hepatocyte growth factor-like protein precursor) | MST1 | Serine threonine kinase |
| PTP1D/SHP2 (Protein-tyrosine phosphatase, non-receptor type 11) | PTP1D | PI3K signaling pathway |
GTPase indicates guanosine triphosphatase; SLP76, SH2-containing leukocyte protein; and c-AMP, cyclic adenosine monophosphate.