Higher than 2-fold change in at least 66% of the 6 MCL patients
Protein . | Corresponding gene . | Function . |
|---|---|---|
| RCC1 (regulator of chromosome condensation) | CHC1 | Cell cycle, DNA binding, Ran guanyl-nucleotide exchange factor activity |
| p43/EMAPII (multisynthetase complex auxiliary component p43) precursor | SCYE1 | Chemotaxis, cell-cell signaling, inflammatory response |
| Inhibitor 2 | PPP1R2 | Type 1 serine/threonine-specific protein phosphatase inhibitor activity |
| AKAP149 (A kinase anchor protein 1, mitochondrial precursor) | AAKAP149 | Protein kinase A anchoring activity |
| CHD3 (chromodomain helicase-DNA-binding protein 3) | CHD3 | ATP-dependent DNA helicase activity, ATP binding |
| PP5 (protein phosphatase 5) | PPP5C | Protein phosphatase type 2C activity, involved in p53 and Hsp90 regulation |
| Caspase-7 | CASP7 | Apoptosis |
| Hsp10 (heat shock protein 10) | HSPE1 | Protein folding, chaperone protein |
| MDM2 (murine double minute 2) | MDM2 | Negative regulation of cell proliferation, oncogenesis |
| Hsp90 (heat shock protein 90) | HSPCA | Protein folding, chaperone protein |
| SH2B (SH2-B homolog) | SH2B | Growth factor, cytokine, and immunoreceptor signaling |
| CRIK (citron Rho-interacting kinase) | CIT | Small GTPase regulatory/interacting protein activity |
| Per2 (period circadian protein 2) | PER2 | Regulator of circadian expression of VEGF mRNA in hypoxic tumors |
Protein . | Corresponding gene . | Function . |
|---|---|---|
| RCC1 (regulator of chromosome condensation) | CHC1 | Cell cycle, DNA binding, Ran guanyl-nucleotide exchange factor activity |
| p43/EMAPII (multisynthetase complex auxiliary component p43) precursor | SCYE1 | Chemotaxis, cell-cell signaling, inflammatory response |
| Inhibitor 2 | PPP1R2 | Type 1 serine/threonine-specific protein phosphatase inhibitor activity |
| AKAP149 (A kinase anchor protein 1, mitochondrial precursor) | AAKAP149 | Protein kinase A anchoring activity |
| CHD3 (chromodomain helicase-DNA-binding protein 3) | CHD3 | ATP-dependent DNA helicase activity, ATP binding |
| PP5 (protein phosphatase 5) | PPP5C | Protein phosphatase type 2C activity, involved in p53 and Hsp90 regulation |
| Caspase-7 | CASP7 | Apoptosis |
| Hsp10 (heat shock protein 10) | HSPE1 | Protein folding, chaperone protein |
| MDM2 (murine double minute 2) | MDM2 | Negative regulation of cell proliferation, oncogenesis |
| Hsp90 (heat shock protein 90) | HSPCA | Protein folding, chaperone protein |
| SH2B (SH2-B homolog) | SH2B | Growth factor, cytokine, and immunoreceptor signaling |
| CRIK (citron Rho-interacting kinase) | CIT | Small GTPase regulatory/interacting protein activity |
| Per2 (period circadian protein 2) | PER2 | Regulator of circadian expression of VEGF mRNA in hypoxic tumors |
CHC1 indicates chromosome condensation 1; SCYE1, small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating); PPP1, protein phosphatase 1, regulatory (inhibitor) subunit 2R2; AKAP1, A kinase (PRKA) anchor protein 1; CHD3, chromodomain helicase DNA binding protein 3; ATP, adenosine triphosphate; PPP5C, protein phosphatase 5, catalytic subunit; CASP7, caspase-7, apoptosis-related cysteine protease; HSPE1, heat shock 10-kDa protein 1 (chaperonin 10); MDM2, Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse); HSPCA, heat shock 90-kDa protein 1; SH2B, Src homology 2B; CRIK, citron (rho-interacting, serine/threonine kinase 21); PER2, period homolog 2; and VEGF, vascular endothelial growth factor.