CD27-defined B-cell subsets in young and elderly subjects
Subject . | Age, y . | % CD27+ . |
|---|---|---|
| Young subjects | ||
| C11 | 19 | 29.8 |
| C12* | 21 | 34.0 |
| C13* | 20 | 32.3 |
| C14* | 23 | 23.8 |
| C15* | 25 | 22.4 |
| Y12 | 23 | 12.9 |
| Y13 | 27 | 42.0 |
| Y14 | 23 | 22.7 |
| Y14 | 26 | 24.8 |
| Y15 | 27 | 16.8 |
| Mean | 23 | 26.2 |
| SD | 3 | 8.6 |
| Elderly subjects | ||
| E01 | 76 | 64.1 |
| E06 | 65 | 39.1 |
| E07 | 79 | 27.3 |
| E08 | 77 | 41.3 |
| E20 | 69 | 45.0 |
| Mean | 73 | 43.4† |
| SD | 6 | 13.4 |
Subject . | Age, y . | % CD27+ . |
|---|---|---|
| Young subjects | ||
| C11 | 19 | 29.8 |
| C12* | 21 | 34.0 |
| C13* | 20 | 32.3 |
| C14* | 23 | 23.8 |
| C15* | 25 | 22.4 |
| Y12 | 23 | 12.9 |
| Y13 | 27 | 42.0 |
| Y14 | 23 | 22.7 |
| Y14 | 26 | 24.8 |
| Y15 | 27 | 16.8 |
| Mean | 23 | 26.2 |
| SD | 3 | 8.6 |
| Elderly subjects | ||
| E01 | 76 | 64.1 |
| E06 | 65 | 39.1 |
| E07 | 79 | 27.3 |
| E08 | 77 | 41.3 |
| E20 | 69 | 45.0 |
| Mean | 73 | 43.4† |
| SD | 6 | 13.4 |
A panel of healthy young and elderly donors that included some individuals (C11-C15) used for studies of B-cell or B-cell subset kinetics and others not studied kinetically (Y12-Y15, E20) was analyzed for the proportion of CD27+ (memory) cells among CD19+ PBMCs.
Indicates that the percentage of CD27+ cells was obtained from the sort windows set up to separate B-cell subsets for kinetic analysis
P < .01 for CD27+ elderly versus young by 2-tailed Student t test