Table 2.

CD27 expression and B-cell kinetics



Proliferation

Disappearance
CD27+
CD27-
CD27+
CD27-
Subject
p
t2, d
p
t2, d
d*
t1/2, d
d*
t1/2, d
C09   1.25   55   0.17   408   7.09   10   10.21   7  
C11   1.52   46   0.29   239   5.26   13   3.52   20  
C12   2.76   25   0.35   198   11.14   6   5.57   12  
C13   1.39   50   0.89   78   0.00    0.00   
C14   5.12   14   0.32   217   8.39   8   0.00   
C15   3.90   18   0.71   98   4.48   15   0.00   
Mean   2.66   26   0.46*  152   6.06   11   3.22   22  
SD
 
1.58
 
-
 
0.28
 
-
 
3.80
 
-
 
4.14
 
-
 


Proliferation

Disappearance
CD27+
CD27-
CD27+
CD27-
Subject
p
t2, d
p
t2, d
d*
t1/2, d
d*
t1/2, d
C09   1.25   55   0.17   408   7.09   10   10.21   7  
C11   1.52   46   0.29   239   5.26   13   3.52   20  
C12   2.76   25   0.35   198   11.14   6   5.57   12  
C13   1.39   50   0.89   78   0.00    0.00   
C14   5.12   14   0.32   217   8.39   8   0.00   
C15   3.90   18   0.71   98   4.48   15   0.00   
Mean   2.66   26   0.46*  152   6.06   11   3.22   22  
SD
 
1.58
 
-
 
0.28
 
-
 
3.80
 
-
 
4.14
 
-
 

Proliferation (p) and disappearance (d*) rate constants modeled for B-cell subpopulations sorted according to CD27 expression, expressed as percent per day. t2 and t1/2 defined as for Table 1.

*

P indicates .02 versus CD27-positive by paired 2-tailed Student t test

defined as for Table 1 

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