Activation sites of pro-tryptase ϵ, pro-uPA, pro-tPA, and plasminogen
. | Zymogen processing site . |
|---|---|
| . | ↓ . |
| Protease . | propeptide-P1-P1′-P2′-P3′-P4′-P5′-mature domain . |
| Human pro-tryptase ϵ | Arg-Val-Val-Gly-Gly-Glu |
| Rat pro-tryptase ϵ | Arg-Val-Val-Gly-Gly-Glu |
| Mouse pro-tryptase ϵ | Arg-Ile-Val-Gly-Gly-Glu |
| Mouse pro-uPA | Lys-Ile-Val-Gly-Gly-Glu |
| Rat pro-uPA | Lys-Ile-Val-Gly-Gly-Glu |
| Human pro-uPA | Lys-Ile-Ile-Gly-Gly-Glu |
| Human pro-tPA | Arg-Ile-Lys-Gly-Gly-Leu |
| Mouse pro-tPA | Arg-Ile-Lys-Gly-Gly-Leu |
| Rat pro-tPA | Arg-Ile-Lys-Gly-Gly-Leu |
| Human plasminogen | Arg-Val-Val-Gly-Gly-Cys |
| Mouse plasminogen | Arg-Val-Val-Gly-Gly-Cys |
| Rat plasminogen | Arg-Val-Val-Gly-Gly-Cys |
| Danio rerio plasminogen | Arg-Ile-Val-Gly-Gly-Cys |
. | Zymogen processing site . |
|---|---|
| . | ↓ . |
| Protease . | propeptide-P1-P1′-P2′-P3′-P4′-P5′-mature domain . |
| Human pro-tryptase ϵ | Arg-Val-Val-Gly-Gly-Glu |
| Rat pro-tryptase ϵ | Arg-Val-Val-Gly-Gly-Glu |
| Mouse pro-tryptase ϵ | Arg-Ile-Val-Gly-Gly-Glu |
| Mouse pro-uPA | Lys-Ile-Val-Gly-Gly-Glu |
| Rat pro-uPA | Lys-Ile-Val-Gly-Gly-Glu |
| Human pro-uPA | Lys-Ile-Ile-Gly-Gly-Glu |
| Human pro-tPA | Arg-Ile-Lys-Gly-Gly-Leu |
| Mouse pro-tPA | Arg-Ile-Lys-Gly-Gly-Leu |
| Rat pro-tPA | Arg-Ile-Lys-Gly-Gly-Leu |
| Human plasminogen | Arg-Val-Val-Gly-Gly-Cys |
| Mouse plasminogen | Arg-Val-Val-Gly-Gly-Cys |
| Rat plasminogen | Arg-Val-Val-Gly-Gly-Cys |
| Danio rerio plasminogen | Arg-Ile-Val-Gly-Gly-Cys |