Clinical and biologic characteristics of 11 patients with nonnodal leukemic MCL
Patient no. . | Age/sex . | IPI . | Splenic disease . | Blood lymphocytes, × 109/L . | CD5/19 . | Score . | IgVH . | VH homology, % . | VH family . | Karyotype . | Aberrant clones Gains; losses . | Deletion 8p21 . | Gain 8q24-MYC . | Survival, mo . | Status . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCL042 | 74/M | 2 | Yes | 50.0 | + | 1/5 | M | 91.89 | VH4-39 | 46,XY (20) | 116; 67 | + | - | 6 | Dead |
| MCL043 | 49/F | 1 | Yes | 16.0 | + | 1/5 | U | 99.08 | VH4-59 | 46,X,-X,,-,del(8)(p11),add(9)(p21),t(11;14)(q13;q32),del(13)(q12q14),add(15)(q26),+mar1-4(cp5) | 25; 1 | + | + | 72 | Dead |
| MCL044 | 73/M | 2 | No | 16.2 | + | 1/4 | M | 92.85 | VH3-23 | 46,XY (20) | 105; 75 | + | + | 43 | Dead |
| MCL045 | 74/M | 2 | No | 21.1 | - | 1/5 | U | 99.1 | VH1-18 | 46,XY,-6,t(11;14)(q13;q32),+mar (5)/46,XY (15) | 12; 0 | - | + | 42 | Dead |
| MCL048 | 77/M | 2 | No | 17.9 | - | 0/5 | M | 96.4 | VH4-39 | 44-46,X,-Y,t(3;10)(p14;q22),dic(8;9)(q10;q10),t(11;14)(q13;q32),del(12)(p11),del(17)(p11),+mar1-5 (cp10) | 146; 111 | + | + | 33 | Dead |
| MCL050 | 63/M | 3 | No | 20.1 | + | 2/5 | M | 95.15 | VH4-39 | 46,XY,t(11;14)(q13;q32)(17) | 20; 1 | - | - | 60 | Alive |
| MCL086 | 55/M | 1 | No | 23.9 | + | 1/5 | U | 100 | VH1-08 | 46-52,XY,t(5;11;14)(p?11;q13;q32),+1-5mar (cp3) | 29; 3 | - | - | 38 | Alive |
| MCL089 | 74/F | 2 | Yes | 18.0 | + | 2/5 | M | 94.54 | VH3-07 | 46,X,t(X;4)(p22;p12),ins(1)(q?22),t(11;14)(q13;q32)(2)/46,XX(19) | 43; 0 | - | - | 94 | Dead |
| MCL104 | 60/F | 3 | No | 9.2 | + | 1/5 | M | 95 | VH4-39 | 46,XX,del(8)(p12),t(11;14)(q13;q32)(4) | 3; 5 | + | - | 82 | Alive |
| MCL111 | 74/F | 2 | Yes | 8.8 | + | 1/5 | M | 95 | VH4-34 | 46,XX (8) | 36; 0 | - | - | 14 | Alive |
| MCL113 | 74/M | 3 | No | 15.6 | - | 0/5 | U | 100 | VH4-59 | 46,XY,dup(3)(q11q29),del(7)(q22q31),i(8)(q11),add(11)(q13),del(17)(p11p13)(2) | 137; 101 | + | + | 29 | Alive |
Patient no. . | Age/sex . | IPI . | Splenic disease . | Blood lymphocytes, × 109/L . | CD5/19 . | Score . | IgVH . | VH homology, % . | VH family . | Karyotype . | Aberrant clones Gains; losses . | Deletion 8p21 . | Gain 8q24-MYC . | Survival, mo . | Status . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCL042 | 74/M | 2 | Yes | 50.0 | + | 1/5 | M | 91.89 | VH4-39 | 46,XY (20) | 116; 67 | + | - | 6 | Dead |
| MCL043 | 49/F | 1 | Yes | 16.0 | + | 1/5 | U | 99.08 | VH4-59 | 46,X,-X,,-,del(8)(p11),add(9)(p21),t(11;14)(q13;q32),del(13)(q12q14),add(15)(q26),+mar1-4(cp5) | 25; 1 | + | + | 72 | Dead |
| MCL044 | 73/M | 2 | No | 16.2 | + | 1/4 | M | 92.85 | VH3-23 | 46,XY (20) | 105; 75 | + | + | 43 | Dead |
| MCL045 | 74/M | 2 | No | 21.1 | - | 1/5 | U | 99.1 | VH1-18 | 46,XY,-6,t(11;14)(q13;q32),+mar (5)/46,XY (15) | 12; 0 | - | + | 42 | Dead |
| MCL048 | 77/M | 2 | No | 17.9 | - | 0/5 | M | 96.4 | VH4-39 | 44-46,X,-Y,t(3;10)(p14;q22),dic(8;9)(q10;q10),t(11;14)(q13;q32),del(12)(p11),del(17)(p11),+mar1-5 (cp10) | 146; 111 | + | + | 33 | Dead |
| MCL050 | 63/M | 3 | No | 20.1 | + | 2/5 | M | 95.15 | VH4-39 | 46,XY,t(11;14)(q13;q32)(17) | 20; 1 | - | - | 60 | Alive |
| MCL086 | 55/M | 1 | No | 23.9 | + | 1/5 | U | 100 | VH1-08 | 46-52,XY,t(5;11;14)(p?11;q13;q32),+1-5mar (cp3) | 29; 3 | - | - | 38 | Alive |
| MCL089 | 74/F | 2 | Yes | 18.0 | + | 2/5 | M | 94.54 | VH3-07 | 46,X,t(X;4)(p22;p12),ins(1)(q?22),t(11;14)(q13;q32)(2)/46,XX(19) | 43; 0 | - | - | 94 | Dead |
| MCL104 | 60/F | 3 | No | 9.2 | + | 1/5 | M | 95 | VH4-39 | 46,XX,del(8)(p12),t(11;14)(q13;q32)(4) | 3; 5 | + | - | 82 | Alive |
| MCL111 | 74/F | 2 | Yes | 8.8 | + | 1/5 | M | 95 | VH4-34 | 46,XX (8) | 36; 0 | - | - | 14 | Alive |
| MCL113 | 74/M | 3 | No | 15.6 | - | 0/5 | U | 100 | VH4-59 | 46,XY,dup(3)(q11q29),del(7)(q22q31),i(8)(q11),add(11)(q13),del(17)(p11p13)(2) | 137; 101 | + | + | 29 | Alive |
Score indicates Matutes score for B-CLL; M, mutated; U, unmutated.