Table 3. Association of genomic... | American Society of Hematology

Table 3.

Association of genomic alterations and clinical and biologic features in patients with MCL

	Blastoid cytology	PB dissemination	BM disease	Splenic disease	IgVH mutation	VH3-23	VH4-34	VH4-59
Gain/amplification
3q26-q27	—	.005	—	—	.01^*	—	—	—
7p21-pte1	.04	.04^*	—	—	—	—	—	—
8q24	—	—	—	—	—	—	—	.04
13q31	< .001†	—	—	—	—	—	—	—
15q21-22	.002†	—	—	—	.005^*	—	—	—
Genomic loss
1p21	—	—	.02	—	—	—	—	—
6q22-q23	—	—	—	—	—	—	.007	—
8p21.3	—	.008	.008	—	—	—	—	—
9p21.3	—	—	—	—	—	.026	—	—
9q21-q22	—	—	—	—	—	—	—	—
11q22.3	—	—	—	.03	—	—	—	—
13q14.2	—	.03^*	—	—	—	—	—	—
13q33-34	—	.007^*	—	—	—	—	—	—
17p13.1	—	.01	.002†	—	—	—	—	—

	Blastoid cytology	PB dissemination	BM disease	Splenic disease	IgVH mutation	VH3-23	VH4-34	VH4-59
Gain/amplification
3q26-q27	—	.005	—	—	.01^*	—	—	—
7p21-pte1	.04	.04^*	—	—	—	—	—	—
8q24	—	—	—	—	—	—	—	.04
13q31	< .001†	—	—	—	—	—	—	—
15q21-22	.002†	—	—	—	.005^*	—	—	—
Genomic loss
1p21	—	—	.02	—	—	—	—	—
6q22-q23	—	—	—	—	—	—	.007	—
8p21.3	—	.008	.008	—	—	—	—	—
9p21.3	—	—	—	—	—	.026	—	—
9q21-q22	—	—	—	—	—	—	—	—
11q22.3	—	—	—	.03	—	—	—	—
13q14.2	—	.03^*	—	—	—	—	—	—
13q33-34	—	.007^*	—	—	—	—	—	—
17p13.1	—	.01	.002†	—	—	—	—	—

Only statistically significant correlations (P < .05) are shown.

These values indicate inverse correlations: Tumors without PB dissemination showed gain of 7p21-pte1 and deletions of 13q14.2 and 13q33-q34; tumors without mutation showed gain of 3q26-q27 and 15q21-q22

†

After adjustments using the FDR test, only these associations remained statistically significant

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