Hematopoietic progenitors detected in fetal livers from knock-in embryos at E12.5
Genotype . | n . | BFU-Es . | CFU-GMs . | CFU-Mix's . | Total . |
|---|---|---|---|---|---|
| AML1-2 mutant | |||||
| +/+ | 3 | 2 ± 1 (115) | 91 ± 42 (5240) | 27 ± 20 (1280) | 120 ± 59 (6635) |
| AML1-2/AML1-2 | 6 | 5 ± 3 (310) | 134 ± 30 (9010) | 59 ± 16 (4020) | 198 ± 40 (13340) |
| AML1-3 mutant | |||||
| +/+ | 11 | 4 ± 4 (116) | 76 ± 15 (11035) | 28 ± 15 (2779) | 108 ± 25 (13930) |
| AML1-3/AML1-3 | 9 | 5 ± 4 (177) | 103 ± 50 (6050) | 32 ± 23 (1421) | 138 ± 66 (7648) |
Genotype . | n . | BFU-Es . | CFU-GMs . | CFU-Mix's . | Total . |
|---|---|---|---|---|---|
| AML1-2 mutant | |||||
| +/+ | 3 | 2 ± 1 (115) | 91 ± 42 (5240) | 27 ± 20 (1280) | 120 ± 59 (6635) |
| AML1-2/AML1-2 | 6 | 5 ± 3 (310) | 134 ± 30 (9010) | 59 ± 16 (4020) | 198 ± 40 (13340) |
| AML1-3 mutant | |||||
| +/+ | 11 | 4 ± 4 (116) | 76 ± 15 (11035) | 28 ± 15 (2779) | 108 ± 25 (13930) |
| AML1-3/AML1-3 | 9 | 5 ± 4 (177) | 103 ± 50 (6050) | 32 ± 23 (1421) | 138 ± 66 (7648) |
Figures show mean ± SD numbers of progenitors per 5000 cultured nucleated cells. Mean numbers of precursor cells per liver are shown in parentheses.
BFU-Es indicates erythroid burst-forming units; CFU-GMs, granulocyte-macrophage colony-forming units; CFU-Mix's, mixed-lineage colony-forming units.