Iron isotopic composition of blood in patients with homozygous C282Y hemochromatosis and control subjects, presented as relative deviation of the 56Fe/54Fe isotope ratio of blood from the isotope ratio of the isotopic reference material IRM-014 (means ± 1 SD)
. | . | Control groups . | . | |
|---|---|---|---|---|
. | Patients with hemochromatosis . | Age-matched controls . | Young adults . | |
| Age (years) | 61.8 ± 10.7 | 61.6 ± 9.8 | 23.6 ± 3.2 | |
| Male gender (%) | 53 | 50 | 47 | |
| δ 56Fe/54Fe (‰), all patients | -2.11 ± 0.47 (n = 30) | -2.72 ± 0.27 (n = 10, P < .001*) | -2.58 ± 0.25 (n = 36, P < .001*) | |
| Male subjects | NA | -2.92 ± 0.22 (n = 5, P < .001†) | -2.75 ± 0.17 (n = 17, P < .001†) | |
| Treated | -1.95 ± 0.40 (n = 12) | NA | NA | |
| Untreated | -2.56 ± 0.37 (n = 4) | NA | NA | |
| Female subjects | NA | -2.52 ± 0.10 (n = 5, P = .025†) | -2.43 ± 0.21 (n = 19, P = .002†) | |
| Treated | -2.02 ± 0.43 (n = 10) | NA | NA | |
| Untreated | -2.35 ± 0.59 (n = 4) | NA | NA | |
. | . | Control groups . | . | |
|---|---|---|---|---|
. | Patients with hemochromatosis . | Age-matched controls . | Young adults . | |
| Age (years) | 61.8 ± 10.7 | 61.6 ± 9.8 | 23.6 ± 3.2 | |
| Male gender (%) | 53 | 50 | 47 | |
| δ 56Fe/54Fe (‰), all patients | -2.11 ± 0.47 (n = 30) | -2.72 ± 0.27 (n = 10, P < .001*) | -2.58 ± 0.25 (n = 36, P < .001*) | |
| Male subjects | NA | -2.92 ± 0.22 (n = 5, P < .001†) | -2.75 ± 0.17 (n = 17, P < .001†) | |
| Treated | -1.95 ± 0.40 (n = 12) | NA | NA | |
| Untreated | -2.56 ± 0.37 (n = 4) | NA | NA | |
| Female subjects | NA | -2.52 ± 0.10 (n = 5, P = .025†) | -2.43 ± 0.21 (n = 19, P = .002†) | |
| Treated | -2.02 ± 0.43 (n = 10) | NA | NA | |
| Untreated | -2.35 ± 0.59 (n = 4) | NA | NA | |