Isolation and characterization of aerolysin-resistant clones from patients with PNH
Patient no./colony no. . | Colony type . | Exon . | Codon . | Position and mutations . | Consequence . |
|---|---|---|---|---|---|
| 1/1 | CFU-GM/AE | 2 | 123 | 452insA | frame shift |
| 1/2 | CFU-GM/AE | 2 | 123 | 452insA | frame shift |
| 1/3 | CFU-GM/AE | 2 | 123 | 452insA | frame shift |
| 1/4 | BFU/AE | 2 | 123 | 452insA | frame shift |
| 1/5 | BFU/AE | 2 | 123 | 452insA | frame shift |
| 2/1 | CFU-GM/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/2 | CFU-GM/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/3 | CFU-GM/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/4 | BFU/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/5 | BFU/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 3/1 | CFU-GM/AE | 2 | 99 | 379C>A | stop codon |
| 3/2 | CFU-GM/AE | 2 | 99 | 379C>A | stop codon |
| 3/3 | BFU/AE | 2 | 99 | 379C>A | stop codon |
| 3/4 | BFU/AE | 2 | 99 | 379C>A | stop codon |
| 4/1 | CFU-GM/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/2 | CFU-GM/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/3 | CFU-GM/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/4 | BFU/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/5 | BFU/AE | 2 | 126 | 461C>T | His→Tyr |
Patient no./colony no. . | Colony type . | Exon . | Codon . | Position and mutations . | Consequence . |
|---|---|---|---|---|---|
| 1/1 | CFU-GM/AE | 2 | 123 | 452insA | frame shift |
| 1/2 | CFU-GM/AE | 2 | 123 | 452insA | frame shift |
| 1/3 | CFU-GM/AE | 2 | 123 | 452insA | frame shift |
| 1/4 | BFU/AE | 2 | 123 | 452insA | frame shift |
| 1/5 | BFU/AE | 2 | 123 | 452insA | frame shift |
| 2/1 | CFU-GM/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/2 | CFU-GM/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/3 | CFU-GM/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/4 | BFU/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 2/5 | BFU/AE | 4 | 296-299 | 972G>A, del 973-980 | frame shift |
| 3/1 | CFU-GM/AE | 2 | 99 | 379C>A | stop codon |
| 3/2 | CFU-GM/AE | 2 | 99 | 379C>A | stop codon |
| 3/3 | BFU/AE | 2 | 99 | 379C>A | stop codon |
| 3/4 | BFU/AE | 2 | 99 | 379C>A | stop codon |
| 4/1 | CFU-GM/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/2 | CFU-GM/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/3 | CFU-GM/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/4 | BFU/AE | 2 | 126 | 461C>T | His→Tyr |
| 4/5 | BFU/AE | 2 | 126 | 461C>T | His→Tyr |