Table 1. F1 progeny of intercrossed... | American Society of Hematology

Table 1.

F1 progeny of intercrossed Akt-1^Het/Pim-1/2^KO mice

F1 progeny	Predicted	Observed at weaning (no./no. total)	Observed at E13.5
Akt-1^WT/Pim-1/2^KO	0.25	0.47 (58/124)^*	0.38 (12/31)
Akt-1^Het/Pim-1/2^KO	0.5	0.46 (57/124)	0.43 (14/31)
Akt-1^KO/Pim-1/2^KO	0.25	0.07 (9/124)^*	0.15 (5/31)†

F1 progeny	Predicted	Observed at weaning (no./no. total)	Observed at E13.5
Akt-1^WT/Pim-1/2^KO	0.25	0.47 (58/124)^*	0.38 (12/31)
Akt-1^Het/Pim-1/2^KO	0.5	0.46 (57/124)	0.43 (14/31)
Akt-1^KO/Pim-1/2^KO	0.25	0.07 (9/124)^*	0.15 (5/31)†

Frequency of generation of each genotype, as determined by tail-snip PCR, is shown.

E13.5 indicates embryonic day 13.5; WT, wild type; KO, knockout; and Het, heterozygous.

P < .001 by χ² analysis

3 of 5 mice were dead in utero