P-Y-specific immunostaining of HRS cells in HL and B-NHL
. | Classical HL . | . | . | . | . | ||
|---|---|---|---|---|---|---|---|
| Specificity of antibody . | AII . | NS . | MC . | LP HL . | B-NHL* . | ||
| P-Y-720-PDGFRA | 6/25† (24) | 6/14 (43) | 0/11 | ND | ND | ||
| P-Y-680/681-TRKA/B | 6/21† (29) | 6/14 (43) | 0/7 | ND | ND | ||
| Pan-p-Y | 27/99 (27) | 21/39 (54) | 6/60 (10) | 1/23 (4) | 9/86 (10) | ||
. | Classical HL . | . | . | . | . | ||
|---|---|---|---|---|---|---|---|
| Specificity of antibody . | AII . | NS . | MC . | LP HL . | B-NHL* . | ||
| P-Y-720-PDGFRA | 6/25† (24) | 6/14 (43) | 0/11 | ND | ND | ||
| P-Y-680/681-TRKA/B | 6/21† (29) | 6/14 (43) | 0/7 | ND | ND | ||
| Pan-p-Y | 27/99 (27) | 21/39 (54) | 6/60 (10) | 1/23 (4) | 9/86 (10) | ||
ND indicates not done.
Twenty-two patients with mantle cell lymphoma, 15 with chronic lymphocytic leukemia, 19 with follicular lymphoma, 11 with Burkitt lymphoma, and 20 with diffuse large B-cell lymphoma
Only patients with PDGFRA and TRKA or TRKB (or both) expression were analyzed. Of the 25 PDGFRA-positive patients, 11 (8 with nodular sclerosis and 3 with mixed cellularity subtype) also showed positivity in the stainings with the pan-phosphotyrosine antibody, and of these 11 patients, 5 showed negativity and 6 showed positivity with the phosphotyrosine-720-PDGFRA-specific antibody. Of the 21 TRKA- and/or TRKB-positive patients, 10 (9 with nodular sclerosis and 1 with mixed cellularity subtype) also showed positivity in stainings with the panphosphotyrosine antibody. Of these 10 patients, 5 showed positivity and 5 showed negativity with the phosphotyrosine-680/681-TRKA/B-specific antibody