Unique issues related to cord blood transplantation
Feature . | Cord blood . | Non-T-cell-depleted unrelated bone marrow/PBSC . |
|---|---|---|
| Graft availability | Limitless supply | Limited supply |
| Matching | 4/6 or better | 10/10 or 9/10 optimal |
| GVHD risk | Reduced risk | High risk |
| Infectious risk after transplantation | Higher | High |
| Graft durability | Up to 16 y | Approximately 30 y |
| Donor lymphocyte infusion | None | Available |
Feature . | Cord blood . | Non-T-cell-depleted unrelated bone marrow/PBSC . |
|---|---|---|
| Graft availability | Limitless supply | Limited supply |
| Matching | 4/6 or better | 10/10 or 9/10 optimal |
| GVHD risk | Reduced risk | High risk |
| Infectious risk after transplantation | Higher | High |
| Graft durability | Up to 16 y | Approximately 30 y |
| Donor lymphocyte infusion | None | Available |
PBSC indicates peripheral blood stem cells.