Integrins expressed on leukocytes and ligands8,,100 ,101
Integrin . | Common name . | Ligands . |
|---|---|---|
| β1 | ||
| α1 | VLA-1 | Collagen, laminin |
| α2 | VLA-2 | Collagen, laminin |
| α3 | VLA-3 | Collagen, laminin, fibronectin |
| α4 | VLA-4 | Collagen, laminin, VCAM-1 |
| α5 | VLA-5 | Fibronectin |
| α6 | VLA-6 | Laminin |
| αV | — | Fibronectin, vitronectin |
| β7 | ||
| α4 | LPAM | MadCAM-1, VCAM-1, fibronectin |
| αE | HML-1 | E-cadherin |
| B2 | ||
| αL | LFA-1 | ICAM-1,2,3 |
| αM | Mac-1 | ICAM-1 |
| αD | — | ICAM-3 |
| αX | CR4 | ICAM-1 |
Integrin . | Common name . | Ligands . |
|---|---|---|
| β1 | ||
| α1 | VLA-1 | Collagen, laminin |
| α2 | VLA-2 | Collagen, laminin |
| α3 | VLA-3 | Collagen, laminin, fibronectin |
| α4 | VLA-4 | Collagen, laminin, VCAM-1 |
| α5 | VLA-5 | Fibronectin |
| α6 | VLA-6 | Laminin |
| αV | — | Fibronectin, vitronectin |
| β7 | ||
| α4 | LPAM | MadCAM-1, VCAM-1, fibronectin |
| αE | HML-1 | E-cadherin |
| B2 | ||
| αL | LFA-1 | ICAM-1,2,3 |
| αM | Mac-1 | ICAM-1 |
| αD | — | ICAM-3 |
| αX | CR4 | ICAM-1 |
Leukocyte integrins separated into β1, β2, and β7 families. Common names are presented for the given αβ heterodimer.
VLA-1 indicates very late antigen-1; HML-1, human mucosal lymphocyte antigen-1; and Mac-1, macrophage antigen-1.