Table 3. Characteristic features of... | American Society of Hematology

Table 3.

Characteristic features of PCFCL and PCLBCL, leg type

	PCFCL	PCLBCL, leg type
Morphology	Predominance of centrocytes that are often large, especially in diffuse lesions.	Predominance or confluent sheets of medium-sized to large B cells with round nuclei, prominent nucleoli, and coarse chromatin resembling centroblasts and/or immunoblasts.
	Centroblasts may be present, but not in confluent sheets.	Diffuse growth pattern.
	Growth pattern may be follicular, follicular and diffuse, or diffuse (a continuum without distinct categories or grades).
Phenotype	Bcl-2: -/+^*	Bcl-2: ++‡
	Bcl-6: +	Bcl-6: +/-
	CD10: -/+†	CD10: -
	Mum-1: -	Mum-1: +
Clinical features	Middle-aged adults.	Elderly, especially females,
	Localized lesions on head or trunk (90%).	Lesions localized on leg(s), most often below the knee.
	Multifocal lesions in rare cases.	Rare cases with lesions at other sites than the leg (10%).

	PCFCL	PCLBCL, leg type
Morphology	Predominance of centrocytes that are often large, especially in diffuse lesions.	Predominance or confluent sheets of medium-sized to large B cells with round nuclei, prominent nucleoli, and coarse chromatin resembling centroblasts and/or immunoblasts.
	Centroblasts may be present, but not in confluent sheets.	Diffuse growth pattern.
	Growth pattern may be follicular, follicular and diffuse, or diffuse (a continuum without distinct categories or grades).
Phenotype	Bcl-2: -/+^*	Bcl-2: ++‡
	Bcl-6: +	Bcl-6: +/-
	CD10: -/+†	CD10: -
	Mum-1: -	Mum-1: +
Clinical features	Middle-aged adults.	Elderly, especially females,
	Localized lesions on head or trunk (90%).	Lesions localized on leg(s), most often below the knee.
	Multifocal lesions in rare cases.	Rare cases with lesions at other sites than the leg (10%).

Faint staining, when present; minority of cells (see comments in paragraph on PCFCL)

Diffuse lesions, mostly CD10^-

Strong staining; in most neoplastic cells