Specificity and potency of CHIR-258 kinase inhibitor
Receptor tyrosine kinases . | CHIR-258 IC50, μM . |
---|---|
FLT3 | 0.001 |
c-KIT | 0.002 |
CSF-1R/c-fms | 0.036 |
FGFR1 | 0.008 |
FGFR3 | 0.009 |
VEGFR1/Flt1 | 0.01 |
VEGFR2/Flk1 | 0.013 |
VEGFR3/Flt4 | 0.008 |
PDGFRβ | 0.027 |
PDGFRα | 0.21 |
InsR | 2 |
EGFR1 | 2 |
c-Met | > 3 |
EphA2 | 4 |
Tie2 | 4 |
IGFR1 | > 10 |
HER2 | > 10 |
Receptor tyrosine kinases . | CHIR-258 IC50, μM . |
---|---|
FLT3 | 0.001 |
c-KIT | 0.002 |
CSF-1R/c-fms | 0.036 |
FGFR1 | 0.008 |
FGFR3 | 0.009 |
VEGFR1/Flt1 | 0.01 |
VEGFR2/Flk1 | 0.013 |
VEGFR3/Flt4 | 0.008 |
PDGFRβ | 0.027 |
PDGFRα | 0.21 |
InsR | 2 |
EGFR1 | 2 |
c-Met | > 3 |
EphA2 | 4 |
Tie2 | 4 |
IGFR1 | > 10 |
HER2 | > 10 |