Table 2. F.IX-specific activity as a... | American Society of Hematology

Table 2.

F.IX-specific activity as a function of expression levels at several time points following intramuscular injection of AAV vectors

	Specific activity for F.IX range, mean ± SEM
AAV-F.IX	50-499 U/mg F.IX, ng/mL	500-1500 U/mg F.IX, ng/mL
WT	123 ± 15	15 ± 2
K5A/V10K	112 ± 16	49 ± 11^*
R338A	305 ± 48†	24 ± 11

	Specific activity for F.IX range, mean ± SEM
AAV-F.IX	50-499 U/mg F.IX, ng/mL	500-1500 U/mg F.IX, ng/mL
WT	123 ± 15	15 ± 2
K5A/V10K	112 ± 16	49 ± 11^*
R338A	305 ± 48†	24 ± 11

ANOVA was used for statistical analysis Tukey-Kramer comparison test between all groups. Data are mean values ± SEM for specific activities.

K5A/V10K compared with WT (P < .01)

R338A compared with WT or K5A/V10K (P < .0001)