Examples of active agents targeting signaling pathways downstream of BCR-ABL
Target . | Compound . | Activity in imatinib-resistant cells . | Clinical trials . | Reference no. . |
|---|---|---|---|---|
| Farnesyl transferase | Lonafarnib Tipifamib | Yes | Yes | 136-139 |
| MEK1 | PD98059 | Yes | No | 140 |
| RAF-1 | BAY43-9006 | Yes | Yes | 141 |
| PI3 kinase | LY294002 Wortmannin | Yes | No | 142 |
| mTOR | Rapamycin | Yes | Yes | 143,144 |
| Cyclin-dependent kinases | Favopiridol | Yes | Yes | 145 |
Target . | Compound . | Activity in imatinib-resistant cells . | Clinical trials . | Reference no. . |
|---|---|---|---|---|
| Farnesyl transferase | Lonafarnib Tipifamib | Yes | Yes | 136-139 |
| MEK1 | PD98059 | Yes | No | 140 |
| RAF-1 | BAY43-9006 | Yes | Yes | 141 |
| PI3 kinase | LY294002 Wortmannin | Yes | No | 142 |
| mTOR | Rapamycin | Yes | Yes | 143,144 |
| Cyclin-dependent kinases | Favopiridol | Yes | Yes | 145 |