Responses to imatinib in blast-crisis and accelerated phases of CML
. | Overall hematologic response/CHR, % . | Sustained hematologic responses, % (> 4 wk) . | MCR, % . | CCR, % . | Median survival, mo . |
---|---|---|---|---|---|
Myeloid blast crisis, n = 229 | 52/15 | 31 | 16 | 7 | 6.8 |
Ph+ ALL*, n = 56 | 59/22 | 27 | NA | NA | 4.9 |
Accelerated phase, % (n = 181) | 82/53 | 69 | 24 | 17 | Not reached |
Chronic phase after failure of IFN therapy | 95% sustained CHR | 95% sustained CHR | 60 | 41 | Not reached |
. | Overall hematologic response/CHR, % . | Sustained hematologic responses, % (> 4 wk) . | MCR, % . | CCR, % . | Median survival, mo . |
---|---|---|---|---|---|
Myeloid blast crisis, n = 229 | 52/15 | 31 | 16 | 7 | 6.8 |
Ph+ ALL*, n = 56 | 59/22 | 27 | NA | NA | 4.9 |
Accelerated phase, % (n = 181) | 82/53 | 69 | 24 | 17 | Not reached |
Chronic phase after failure of IFN therapy | 95% sustained CHR | 95% sustained CHR | 60 | 41 | Not reached |
MCR indicates major cytogenetic response; CCR, complete cytogenetic response; NA, not available; and CHR, complete hematologic response.
Also lymphoid blast crisis of CML.