Table 2.

Responses to imatinib in blast-crisis and accelerated phases of CML




Overall hematologic response/CHR, %

Sustained hematologic responses, % (> 4 wk)

MCR, %

CCR, %

Median survival, mo
Myeloid blast crisis, n = 229   52/15   31   16   7   6.8  
Ph+ ALL*, n = 56   59/22   27   NA   NA   4.9  
Accelerated phase, % (n = 181)   82/53   69   24   17   Not reached  
Chronic phase after failure of IFN therapy
 
95% sustained CHR
 
95% sustained CHR
 
60
 
41
 
Not reached
 



Overall hematologic response/CHR, %

Sustained hematologic responses, % (> 4 wk)

MCR, %

CCR, %

Median survival, mo
Myeloid blast crisis, n = 229   52/15   31   16   7   6.8  
Ph+ ALL*, n = 56   59/22   27   NA   NA   4.9  
Accelerated phase, % (n = 181)   82/53   69   24   17   Not reached  
Chronic phase after failure of IFN therapy
 
95% sustained CHR
 
95% sustained CHR
 
60
 
41
 
Not reached
 

MCR indicates major cytogenetic response; CCR, complete cytogenetic response; NA, not available; and CHR, complete hematologic response.

*

Also lymphoid blast crisis of CML.

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