Table 4. Engraftment levels in NOD/SCID... | American Society of Hematology

Table 4.

Engraftment levels in NOD/SCID mice receiving secondary transplantation

		Phenotype of engrafted cells
		BM*			Spleen*
Patient	Animal	CD34	CD33	CD33	CD3	CD45^- VWF⁺ cells			BCR/ABL⁺ cells FISH
5	2	2.5	55	ND	49	+†	+	+	+
7	3	4.9	71	0	53	+	+	+	+
13	5	1.6	59	ND	57	+	+	+	+
	SR-1	1.8	47	2	47	+	+	+	+
	SR-2	3.1	81	3	51	+	+	+	+
	SR-3	2.4	62	2	62	+	+	+	+

		Phenotype of engrafted cells
		BM*			Spleen*
Patient	Animal	CD34	CD33	CD33	CD3	CD45^- VWF⁺ cells			BCR/ABL⁺ cells FISH
5	2	2.5	55	ND	49	+†	+	+	+
7	3	4.9	71	0	53	+	+	+	+
13	5	1.6	59	ND	57	+	+	+	+
	SR-1	1.8	47	2	47	+	+	+	+
	SR-2	3.1	81	3	51	+	+	+	+
	SR-3	2.4	62	2	62	+	+	+	+

For SR-1, SR-2, and SR-3, bone marrow cells from animals 2, 3, and 5 were collected and transplanted into secondary recipients (2 × 10⁷ cells per mouse).

Results are percentage of CD45⁺ cells expressing the denoted antigen.

†

Human cells that are CD45^- VWF⁺ or BCR/ABL⁺.

View Large

This Feature Is Available To Subscribers Only