Table 5. Patient characteristics in... | American Society of Hematology

Table 5.

Patient characteristics in relation to apoptosis profile

	Apoptosis profile
Characteristic	Caspase 8 inhibition n = 11	Caspase 8 and 9 inhibition n = 45	Caspase 9 inhibition n = 24	P^*
Median age, y (range)	62 (47-70)	63 (14-82)	60 (26-94)	NS§
Sex
Male	7	24	17	NS
Female	4	21	7
Stage†
1 + 2	6	16	12	NS
3 + 4	5	29	11
B symptoms
Yes	0	17	9	.05
No	11	28	15
IPI†
Low/low-intermediate	7	23	15	NS
Intermediate-high/high	4	22	8
Therapy
CHOP-like	5	26	16	NS
CHOP-like + RT	6	19	8
Complete remission
Yes	11	34	9	Less than .001
No	0	11	15
Relapse‡
Yes	1	15	3	NS
No	10	19	6
Death
Yes	0	27	19	Less than .001
No	11	18	5

	Apoptosis profile
Characteristic	Caspase 8 inhibition n = 11	Caspase 8 and 9 inhibition n = 45	Caspase 9 inhibition n = 24	P^*
Median age, y (range)	62 (47-70)	63 (14-82)	60 (26-94)	NS§
Sex
Male	7	24	17	NS
Female	4	21	7
Stage†
1 + 2	6	16	12	NS
3 + 4	5	29	11
B symptoms
Yes	0	17	9	.05
No	11	28	15
IPI†
Low/low-intermediate	7	23	15	NS
Intermediate-high/high	4	22	8
Therapy
CHOP-like	5	26	16	NS
CHOP-like + RT	6	19	8
Complete remission
Yes	11	34	9	Less than .001
No	0	11	15
Relapse‡
Yes	1	15	3	NS
No	10	19	6
Death
Yes	0	27	19	Less than .001
No	11	18	5

RT indicates radiotherapy; NS, not significant.

As determined by Fisher exact test, unless stated otherwise

Data concerning stage and IPI could not be retrieved for 1 patient

Patients in relapse were those who did reach complete remission

As determined by Mann-Whitney U test