Idd loci in the NOD B10 mice and the effect of the B10 gene on autoimmunity
Locus . | Chromosome . | Effect of congenic on diabetes . | Candidate factors . | Reference . |
|---|---|---|---|---|
| Idd3 | 3 | Complete diabetes resistance when linked with Idd10 and Idd18 | IL2 | 39-41 |
| Idd10 | 3 | Complete diabetes resistance when linked with Idd3 and Idd18 | CD53, Kcna3 | 42 |
| Idd18 | 3 | Complete diabetes resistance when linked with Idd3 and Idd10 | CD53, Kcna3 | 43 |
| Idd3/10/18 | Reduces diabetes and insulitis incidence | IL2, CD53, Kena3 | 43 | |
| Idd5 | 1 | Reduces diabetes and insulitis incidence | FLIP, CD28, CTLA4, Nramp | 43, 44 |
| Idd9.1/9.2/9.3 | 4 | Near-complete protection from diabetes, all progress to insulitis | TNFR superfamily molecules | 2 |
| Idd9.1 | 4 | Near-complete protection from diabetes, all progress to insulitis | Ick, insulin-like protein 5, sno | 2 |
| Idd9.2* | 4 | Near-complete protection from diabetes, all progress to insulitis | TNFR-II, CD30, CD137, ski | 2 |
| Idd9.3 | 4 | Near-complete protection from diabetes, all progress to insulitis | CD137 CD134 | 2 |
Locus . | Chromosome . | Effect of congenic on diabetes . | Candidate factors . | Reference . |
|---|---|---|---|---|
| Idd3 | 3 | Complete diabetes resistance when linked with Idd10 and Idd18 | IL2 | 39-41 |
| Idd10 | 3 | Complete diabetes resistance when linked with Idd3 and Idd18 | CD53, Kcna3 | 42 |
| Idd18 | 3 | Complete diabetes resistance when linked with Idd3 and Idd10 | CD53, Kcna3 | 43 |
| Idd3/10/18 | Reduces diabetes and insulitis incidence | IL2, CD53, Kena3 | 43 | |
| Idd5 | 1 | Reduces diabetes and insulitis incidence | FLIP, CD28, CTLA4, Nramp | 43, 44 |
| Idd9.1/9.2/9.3 | 4 | Near-complete protection from diabetes, all progress to insulitis | TNFR superfamily molecules | 2 |
| Idd9.1 | 4 | Near-complete protection from diabetes, all progress to insulitis | Ick, insulin-like protein 5, sno | 2 |
| Idd9.2* | 4 | Near-complete protection from diabetes, all progress to insulitis | TNFR-II, CD30, CD137, ski | 2 |
| Idd9.3 | 4 | Near-complete protection from diabetes, all progress to insulitis | CD137 CD134 | 2 |
Table data obtained from Mouse Genome Informatics.45
9.2/9.3 congenic: delayed diabetes progression, decreased incidence of diabetes; there is no congenic with only 9.1 or 9.2 alone