Surface expression of the HLA-class I molecules and the ligands for DNAM-1 and NKG2D triggering receptors in lymphoblastic leukemias
. | . | . | DNAM-1 ligands . | . | NKG2D ligands . | |
|---|---|---|---|---|---|---|
| Patient no. . | Type . | HLA-I . | Nectin-2 . | PVR . | MICA/B and ULBPs . | |
| LL1 | Undifferentiated | 1183* | 23 | 4 | NEG | |
| LL2 | Undifferentiated | 275 | 13 | 1 | NEG | |
| LL3 | Pre-T ALL | 158 | 1 | 3 | ULBP1 (6)† | |
| LL4 | Pre-T ALL | 100 | 1 | 1 | NEG | |
| LL5 | Pre-T ALL | 101 | 1 | 2 | 11% ULBP2 (38) | |
| LL6 | T-ALL | 1545 | 1 | 6 | NEG | |
| LL7 | Common ALL‡ | 600 | 1 | 1 | NEG | |
| LL8 | Common ALL | 625 | 35%(16) | 1 | NEG | |
| LL9 | Common ALL | 293 | 18%(10) | 1 | 25% ULBP2 (30) | |
| LL10 | Common ALL | 757 | 25 | 1 | NEG | |
| LL11 | Common ALL | 1750 | 1 | 2 | NEG | |
| LL12 | B-CLL | 520 | 1 | 7 | NEG | |
| LL13 | B-CLL | 1381 | 1 | 1 | NEG | |
| LL14 | B-CLL | 532 | 1 | 1 | NEG | |
. | . | . | DNAM-1 ligands . | . | NKG2D ligands . | |
|---|---|---|---|---|---|---|
| Patient no. . | Type . | HLA-I . | Nectin-2 . | PVR . | MICA/B and ULBPs . | |
| LL1 | Undifferentiated | 1183* | 23 | 4 | NEG | |
| LL2 | Undifferentiated | 275 | 13 | 1 | NEG | |
| LL3 | Pre-T ALL | 158 | 1 | 3 | ULBP1 (6)† | |
| LL4 | Pre-T ALL | 100 | 1 | 1 | NEG | |
| LL5 | Pre-T ALL | 101 | 1 | 2 | 11% ULBP2 (38) | |
| LL6 | T-ALL | 1545 | 1 | 6 | NEG | |
| LL7 | Common ALL‡ | 600 | 1 | 1 | NEG | |
| LL8 | Common ALL | 625 | 35%(16) | 1 | NEG | |
| LL9 | Common ALL | 293 | 18%(10) | 1 | 25% ULBP2 (30) | |
| LL10 | Common ALL | 757 | 25 | 1 | NEG | |
| LL11 | Common ALL | 1750 | 1 | 2 | NEG | |
| LL12 | B-CLL | 520 | 1 | 7 | NEG | |
| LL13 | B-CLL | 1381 | 1 | 1 | NEG | |
| LL14 | B-CLL | 532 | 1 | 1 | NEG | |
Values indicate the MRFI (see “Materials and methods”). When the molecule is not expressed on all leukemic cells, the percentage of positive cells is also indicated and the MRFI is within parentheses
Only the expressed molecules among MICA and ULBP1-4 are indicated, and the values within parentheses represent the MRFI. When the molecule is not expressed on all leukemic cells, the percentage of positive cells is also indicated
Common ALLs are represented by early pre-B CD10+ ALL