Table 1. HLA-class I haplotype of 2... | American Society of Hematology

Table 1.

HLA-class I haplotype of 2 patients and hypothetical NK donors

Patients and NK donors	HLA-A	HLA-B	HLA-C	KIR ligand incompatibility	KIR phenotype of donor's alloreactive NK cells
ML2^*	A2	B15, 50 (Bw6)	Cw12, w6 (C^Asn80, C^Lys80)	—	—
Donor A	A2	B15, 44 (Bw6, w4)	Cw12, w5 (C^Asn80, C^Lys80)	Bw4#	KIR3DL1⁺ KIR2DL1^-, 2/3^-†
Donor B	A2, 3	B35, 44 (Bw6, w4)	Cw3, w5 (C^Asn80, C^Lys80)	Bw4	KIR3DL1⁺ KIR2DL1^-, 2/3^-
ML11	A1, 32	B8, 49 (Bw6, w4)	Cw7 (C^Asn80)	—	—
Donor C	A1, 68	B8, 44 (Bw6, w4)	Cw7, w2 (C^Asn80, C^Lys80)	C^Lys80	KIR2DL1⁺ KIR2DL2/3^-, 3DL1^-
Donor D	A2, 3	B7, 18 (Bw6)	Cw7, w5 (C^Asn80, C^Lys80)	C^Lys80	KIR2DL1⁺ KIR2DL2/3^-, 3DL1^-

Patients and NK donors	HLA-A	HLA-B	HLA-C	KIR ligand incompatibility	KIR phenotype of donor's alloreactive NK cells
ML2^*	A2	B15, 50 (Bw6)	Cw12, w6 (C^Asn80, C^Lys80)	—	—
Donor A	A2	B15, 44 (Bw6, w4)	Cw12, w5 (C^Asn80, C^Lys80)	Bw4#	KIR3DL1⁺ KIR2DL1^-, 2/3^-†
Donor B	A2, 3	B35, 44 (Bw6, w4)	Cw3, w5 (C^Asn80, C^Lys80)	Bw4	KIR3DL1⁺ KIR2DL1^-, 2/3^-
ML11	A1, 32	B8, 49 (Bw6, w4)	Cw7 (C^Asn80)	—	—
Donor C	A1, 68	B8, 44 (Bw6, w4)	Cw7, w2 (C^Asn80, C^Lys80)	C^Lys80	KIR2DL1⁺ KIR2DL2/3^-, 3DL1^-
Donor D	A2, 3	B7, 18 (Bw6)	Cw7, w5 (C^Asn80, C^Lys80)	C^Lys80	KIR2DL1⁺ KIR2DL2/3^-, 3DL1^-

Leukemic patients are indicated in bold

The HLA-class I group present in NK donor but absent in patient (ie, that determining KIR/ligand mismatch in graft-versus-host direction)

Expected KIR phenotype of donor's NK cells displaying alloreactivity against the respective leukemic patient