Table 2. IC 50 adaphostin dose levels by... | American Society of Hematology

Table 2.

IC₅₀ adaphostin dose levels by prognostic groups

Factor	No.	Median IC₅₀ adaphostin	Range	P
Rai stage group				.018
Low/intermediate: 0-II	19	4.70	1.8-11.25
High: III-IV	10	3.05	1.1-5.4
IgV_H mutation status				.72
Mutated^*	11	4.45	1.1-11.25
Nonmutated	10	3.93	1.8-5.8
CD38 status†				.74
Negative	20	4.55	1.1-11.25
Positive	9	4.25	1.8-6.6
FISH defects‡				.83
13q^-	8	4.70	1.75-11.25
Normal	6	3.53	1.1-5.8
12+	4	3.93	2.25-6.6
17p/11q	5	4.20	2.0-5.4

Factor	No.	Median IC₅₀ adaphostin	Range	P
Rai stage group				.018
Low/intermediate: 0-II	19	4.70	1.8-11.25
High: III-IV	10	3.05	1.1-5.4
IgV_H mutation status				.72
Mutated^*	11	4.45	1.1-11.25
Nonmutated	10	3.93	1.8-5.8
CD38 status†				.74
Negative	20	4.55	1.1-11.25
Positive	9	4.25	1.8-6.6
FISH defects‡				.83
13q^-	8	4.70	1.75-11.25
Normal	6	3.53	1.1-5.8
12+	4	3.93	2.25-6.6
17p/11q	5	4.20	2.0-5.4

Two percent or more deviation from germline IgV_H sequence

Negative indicates less than 30% of CLL B cells expressing CD38; positive, 30% or more CLL B cells expressing CD38

FISH defects were found using a CLL FISH panel using cutoffs from normal controls as previously described²³