DLBCL consensus cluster signatures
Function . | Gene . |
|---|---|
| OxPhos cluster | |
| NADH dehydrogenase complex | NADH dehydrogenase (ubiquinone) 1:α/β subcomplex 1, 8 kDa; β subcomplex 1, 7 kDa; β subcomplex 2, 8 kDa Ubiquinol-cytochrome c reductase hinge protein |
| Cytochrome c/cytochrome oxidase (COX) complex | Cytochrome c COX 5b, 6a1, 7a2L, 7b, 7c, 11 |
| ATP synthase, mitochrondrial | F0 complex, subunit c |
| F1 complex β polypeptide, γ polypeptide 1 and O subunit | |
| ATP other | ATP binding protein |
| ATP binding cassette subfamily D (ALD, member 3) | |
| ATPase H+ transporting, lysosomal: 21 kDa, VO subunit c and 9 kDa | |
| Other, mitochondrial | Translocases of inner mitochondrial membrane (TIMM): nos. 8B and 23 |
| Translocases of outer mitochondrial membrane (TOMM): nos. 7 and 20 | |
| Diazepam binding inhibitor | |
| Apoptosis | BFL-1/A1 |
| MIHC (BIRC3) | |
| TNFA1P8 (SCC-S2) | |
| TNFRSF6 (FAS) | |
| Apoptosis-related protein (APR-3) | |
| Proteosome | Proteosome subunits: α types 2, 5, 6, and 7; and β type 4 |
| Proteosome 26s subunits: ATPase 2 and non-ATPase 4 | |
| Ribosome, mitochondrial | L3, L15, L39, S17, S31, and S36 |
| Ribosome, other | L3, L4, L5, L10, L13a, L15, L17, L27, L30, L31, L36A, L36, large PO, S12, S17, S20, and S21 |
| Other | X-ray repair complementing defective repair 5 (XRCC5) |
| Superoxide dismutase 1 (SOD1) | |
| Jumping translocation breakpoint | |
| CDW52 | |
| H2AZ | |
| PTEN | |
| BCR/proliferation cluster | |
| BCR signaling cascade | CD22 |
| CD19 | |
| Igμ | |
| CD79a | |
| BLK | |
| SYK | |
| PLC γ 2 | |
| Inositol 1, 4, 5 triphosphate receptor type 3 | |
| Inositol 1, 4, 5 triphosphate 3 kinase B | |
| Inositol polyphosphate-5-phosphatase 145 kDa | |
| MAP4K1 | |
| Class II molecules | CD74 (invariant polypeptide MHC class II) |
| Transcription factors | PAX5 |
| FOXO1A | |
| BCL6 | |
| POU2AF1 (BOB-1/OBF-1/OCAB) | |
| STAT6 | |
| TCF3 (E2A) | |
| NFAT | |
| SPI-B | |
| ETS-1 (E26 homolog) | |
| Ikaros | |
| MYC | |
| Other B-cell markers | CD37 |
| BC11A | |
| Proliferation | KI67 |
| CDK2 | |
| Signal-induced proliferation-associated 1 like 3 | |
| Replication/repair | DEAD/H box polypeptides 11 and 39 |
| Postmeiotic segregation increased (PMS) 2-like 2, 6, and 9 | |
| Minichromosome maintenance deficient (MCM) 2, 4, 5, and 7 | |
| p53 | |
| H2AX | |
| PAX transactivation domain-interacting protein (PTIP) | |
| MUTL homolog 6 | |
| Motility/cytoskeletal | Villin 2 (Ezrin) |
| Transcription modulators | SMARC A4, B1, and F1 |
| Posttranscriptional modification | HDAC1 |
| MYST histone acetyltransferase 4 | |
| Ubiquitin-activating enzyme E1 | |
| Other | Heat shock protein 90 beta |
| Host response cluster | |
| T/NK cell | T-cell receptor α and β |
| CD2 | |
| CD3 δ, ϵ and γ | |
| CD6 | |
| CD28 | |
| GATA3 | |
| cMAF | |
| CXCR6 | |
| LST (NKp30) | |
| Zap70 | |
| Linker for activation of T-cells (LAT) | |
| FYN | |
| FYN binding protein (SLAP) | |
| Lymphocyte activation gene 3 (LAG3)* | |
| CD100 (Sema 4D) | |
| Perforin | |
| NK transcript 4* | |
| T-cell immune regulator (TIRC7) | |
| Leukocyte-associated Ig-like receptor 1 (LAIR-1) | |
| Complement | Complement 1qB, 1S, and 4A |
| Complement 3α receptor | |
| Clade G (C1 inhibitor) | |
| Monocyte/macrophage | CD14* |
| CD163 | |
| B lymphocyte activator, macrophage expressed (BLAME) | |
| FGR | |
| SHPS-1 (BIT/SIRPα) | |
| Granulin | |
| Allograft inflammatory factor | |
| Antigen processing | Lysosomal-associated membrane protein 1 (LAMP1)* |
| Cathepsins B and D | |
| IFN—γ inducible protein 30 (GILT)* | |
| Interferon (IFN) | IFN-induced transmembrane proteins 1 and 2 |
| Guanylate binding proteins 1** and 2, IFN-inducible | |
| STAT1* | |
| Interferon regulatory factors (IRFs) 1 and 7 | |
| MHC Class I | HLA A, C, E and F |
| TNF family members | TNFRSF 1A and B |
| TNFSF10 (TRAIL) | |
| TNFSF13 (APRIL)* | |
| Cytokine receptors | IL 2 receptor γ |
| IL 6 receptor | |
| IL 15 receptor α* | |
| TGF β receptor II | |
| CSF-1 receptor* | |
| ECM/adhesion | LFA-1 (integrins α L and β 2)* |
| PECAM1 (CD31) | |
| P-selectin glycoprotein ligand (PSGL-1) | |
| Collagens: type XVIII α 1 and type IV α 2 | |
| Stromal-derived factor 1 | |
| Apoptosis | Caspase 4, apoptosis-related cysteine protease* |
| Other | Notch 2 |
| Disabled homolog 2 (DAB2) | |
| FOXO3A | |
| MAF B | |
| Prostaglandin E receptor 4 | |
| S100A4 |
Function . | Gene . |
|---|---|
| OxPhos cluster | |
| NADH dehydrogenase complex | NADH dehydrogenase (ubiquinone) 1:α/β subcomplex 1, 8 kDa; β subcomplex 1, 7 kDa; β subcomplex 2, 8 kDa Ubiquinol-cytochrome c reductase hinge protein |
| Cytochrome c/cytochrome oxidase (COX) complex | Cytochrome c COX 5b, 6a1, 7a2L, 7b, 7c, 11 |
| ATP synthase, mitochrondrial | F0 complex, subunit c |
| F1 complex β polypeptide, γ polypeptide 1 and O subunit | |
| ATP other | ATP binding protein |
| ATP binding cassette subfamily D (ALD, member 3) | |
| ATPase H+ transporting, lysosomal: 21 kDa, VO subunit c and 9 kDa | |
| Other, mitochondrial | Translocases of inner mitochondrial membrane (TIMM): nos. 8B and 23 |
| Translocases of outer mitochondrial membrane (TOMM): nos. 7 and 20 | |
| Diazepam binding inhibitor | |
| Apoptosis | BFL-1/A1 |
| MIHC (BIRC3) | |
| TNFA1P8 (SCC-S2) | |
| TNFRSF6 (FAS) | |
| Apoptosis-related protein (APR-3) | |
| Proteosome | Proteosome subunits: α types 2, 5, 6, and 7; and β type 4 |
| Proteosome 26s subunits: ATPase 2 and non-ATPase 4 | |
| Ribosome, mitochondrial | L3, L15, L39, S17, S31, and S36 |
| Ribosome, other | L3, L4, L5, L10, L13a, L15, L17, L27, L30, L31, L36A, L36, large PO, S12, S17, S20, and S21 |
| Other | X-ray repair complementing defective repair 5 (XRCC5) |
| Superoxide dismutase 1 (SOD1) | |
| Jumping translocation breakpoint | |
| CDW52 | |
| H2AZ | |
| PTEN | |
| BCR/proliferation cluster | |
| BCR signaling cascade | CD22 |
| CD19 | |
| Igμ | |
| CD79a | |
| BLK | |
| SYK | |
| PLC γ 2 | |
| Inositol 1, 4, 5 triphosphate receptor type 3 | |
| Inositol 1, 4, 5 triphosphate 3 kinase B | |
| Inositol polyphosphate-5-phosphatase 145 kDa | |
| MAP4K1 | |
| Class II molecules | CD74 (invariant polypeptide MHC class II) |
| Transcription factors | PAX5 |
| FOXO1A | |
| BCL6 | |
| POU2AF1 (BOB-1/OBF-1/OCAB) | |
| STAT6 | |
| TCF3 (E2A) | |
| NFAT | |
| SPI-B | |
| ETS-1 (E26 homolog) | |
| Ikaros | |
| MYC | |
| Other B-cell markers | CD37 |
| BC11A | |
| Proliferation | KI67 |
| CDK2 | |
| Signal-induced proliferation-associated 1 like 3 | |
| Replication/repair | DEAD/H box polypeptides 11 and 39 |
| Postmeiotic segregation increased (PMS) 2-like 2, 6, and 9 | |
| Minichromosome maintenance deficient (MCM) 2, 4, 5, and 7 | |
| p53 | |
| H2AX | |
| PAX transactivation domain-interacting protein (PTIP) | |
| MUTL homolog 6 | |
| Motility/cytoskeletal | Villin 2 (Ezrin) |
| Transcription modulators | SMARC A4, B1, and F1 |
| Posttranscriptional modification | HDAC1 |
| MYST histone acetyltransferase 4 | |
| Ubiquitin-activating enzyme E1 | |
| Other | Heat shock protein 90 beta |
| Host response cluster | |
| T/NK cell | T-cell receptor α and β |
| CD2 | |
| CD3 δ, ϵ and γ | |
| CD6 | |
| CD28 | |
| GATA3 | |
| cMAF | |
| CXCR6 | |
| LST (NKp30) | |
| Zap70 | |
| Linker for activation of T-cells (LAT) | |
| FYN | |
| FYN binding protein (SLAP) | |
| Lymphocyte activation gene 3 (LAG3)* | |
| CD100 (Sema 4D) | |
| Perforin | |
| NK transcript 4* | |
| T-cell immune regulator (TIRC7) | |
| Leukocyte-associated Ig-like receptor 1 (LAIR-1) | |
| Complement | Complement 1qB, 1S, and 4A |
| Complement 3α receptor | |
| Clade G (C1 inhibitor) | |
| Monocyte/macrophage | CD14* |
| CD163 | |
| B lymphocyte activator, macrophage expressed (BLAME) | |
| FGR | |
| SHPS-1 (BIT/SIRPα) | |
| Granulin | |
| Allograft inflammatory factor | |
| Antigen processing | Lysosomal-associated membrane protein 1 (LAMP1)* |
| Cathepsins B and D | |
| IFN—γ inducible protein 30 (GILT)* | |
| Interferon (IFN) | IFN-induced transmembrane proteins 1 and 2 |
| Guanylate binding proteins 1** and 2, IFN-inducible | |
| STAT1* | |
| Interferon regulatory factors (IRFs) 1 and 7 | |
| MHC Class I | HLA A, C, E and F |
| TNF family members | TNFRSF 1A and B |
| TNFSF10 (TRAIL) | |
| TNFSF13 (APRIL)* | |
| Cytokine receptors | IL 2 receptor γ |
| IL 6 receptor | |
| IL 15 receptor α* | |
| TGF β receptor II | |
| CSF-1 receptor* | |
| ECM/adhesion | LFA-1 (integrins α L and β 2)* |
| PECAM1 (CD31) | |
| P-selectin glycoprotein ligand (PSGL-1) | |
| Collagens: type XVIII α 1 and type IV α 2 | |
| Stromal-derived factor 1 | |
| Apoptosis | Caspase 4, apoptosis-related cysteine protease* |
| Other | Notch 2 |
| Disabled homolog 2 (DAB2) | |
| FOXO3A | |
| MAF B | |
| Prostaglandin E receptor 4 | |
| S100A4 |
Gene lists derived from the top 250 genes with higher levels of expression in the indicated consensus cluster.
Genes included in previously described LN signature.5