Gene set enrichment analysis of the DLBCL consensus clusters
. | Ox Phos . | . | BCR/proliferation . | . | Host response . | . | |||
|---|---|---|---|---|---|---|---|---|---|
. | KS . | MHT P . | KS . | MHT P . | KS . | MHT P . | |||
| Mitochondrial pathways | |||||||||
| PGC | 130.9 | .004 | 13.2 | .763 | 3.8 | .931 | |||
| VOXPHOS | 156.1 | .001 | 13.3 | .760 | 2.9 | .948 | |||
| Human mito DB | 152.6 | .002 | 11.8 | .790 | 0.6 | .987 | |||
| Mitochondrial | 157.5 | .001 | 16.2 | .703 | 0.4 | .991 | |||
| OXPHOS | 141.0 | .003 | 13.7 | .753 | 2.9 | .946 | |||
| Gen MAPP | |||||||||
| Electron transport | 148.1 | .000 | 14.4 | .641 | 3.1 | .839 | |||
| Cell cycle | 33.4 | .298 | 104.8 | .004 | 0.8 | .873 | |||
| Complement activation-classical | 11.9 | .685 | 7.4 | .766 | 105.9 | .004 | |||
| Bio Carta | |||||||||
| Complement | 12.0 | .745 | 6.4 | .846 | 91.7 | .004 | |||
| T cytotoxic | 8.5 | .809 | 7.0 | .835 | 113.5 | .000 | |||
| T helper | 8.5 | .809 | 7.0 | .835 | 113.5 | .000 | |||
| T ob 1 | 27.0 | .440 | 2.8 | .902 | 103.2 | .002 | |||
| Coregulated gene sets | |||||||||
| C7 | 26.2 | .494 | 7.4 | .870 | 164.6 | .001 | |||
| C10 | 130.5 | .004 | 1.4 | .98 | 19.7 | .62 | |||
| Additional DLBCL gene sets | |||||||||
| Proliferation | 120.4 | .103 | 142.0 | .064 | 3.1 | .854 | |||
| Lymph node | 24.3 | .577 | 1.7 | .902 | 279.7 | .000 | |||
. | Ox Phos . | . | BCR/proliferation . | . | Host response . | . | |||
|---|---|---|---|---|---|---|---|---|---|
. | KS . | MHT P . | KS . | MHT P . | KS . | MHT P . | |||
| Mitochondrial pathways | |||||||||
| PGC | 130.9 | .004 | 13.2 | .763 | 3.8 | .931 | |||
| VOXPHOS | 156.1 | .001 | 13.3 | .760 | 2.9 | .948 | |||
| Human mito DB | 152.6 | .002 | 11.8 | .790 | 0.6 | .987 | |||
| Mitochondrial | 157.5 | .001 | 16.2 | .703 | 0.4 | .991 | |||
| OXPHOS | 141.0 | .003 | 13.7 | .753 | 2.9 | .946 | |||
| Gen MAPP | |||||||||
| Electron transport | 148.1 | .000 | 14.4 | .641 | 3.1 | .839 | |||
| Cell cycle | 33.4 | .298 | 104.8 | .004 | 0.8 | .873 | |||
| Complement activation-classical | 11.9 | .685 | 7.4 | .766 | 105.9 | .004 | |||
| Bio Carta | |||||||||
| Complement | 12.0 | .745 | 6.4 | .846 | 91.7 | .004 | |||
| T cytotoxic | 8.5 | .809 | 7.0 | .835 | 113.5 | .000 | |||
| T helper | 8.5 | .809 | 7.0 | .835 | 113.5 | .000 | |||
| T ob 1 | 27.0 | .440 | 2.8 | .902 | 103.2 | .002 | |||
| Coregulated gene sets | |||||||||
| C7 | 26.2 | .494 | 7.4 | .870 | 164.6 | .001 | |||
| C10 | 130.5 | .004 | 1.4 | .98 | 19.7 | .62 | |||
| Additional DLBCL gene sets | |||||||||
| Proliferation | 120.4 | .103 | 142.0 | .064 | 3.1 | .854 | |||
| Lymph node | 24.3 | .577 | 1.7 | .902 | 279.7 | .000 | |||
GSEA was performed using gene sets from (1) Biocarta; (2) GenMapp; and (3) a series of manually curated pathways involved in mitrochondrial function and metabolism (Mitrochondrial pathways).15 Additional coregulated gene sets from normal murine tissues (Coregulated gene sets)15 and DLBCLs (DLBCL gene sets)5 were also used. KS indicates Kolmogorov-Smirnoff score, and MHT P connotes a P value corrected for multiple hypothesis testing.