Karyotype, allele ratios, and parental origin of duplicated chromosome 14
. | . | Allele ratio* . | . | . | . | ||
|---|---|---|---|---|---|---|---|
| Case . | Karyotype . | D14S587 . | D14S617 . | D14S306 . | Origin +14 . | ||
| 1728 | 53-57, XX, +X, +X, dic(1;6) (p13;q25), +10, +11, +13, +14, +17, +18, +21, +22 [cp4]/46,XX[5] | 1.72 | — | — | Paternal | ||
| 1730 | 46,XX,del(6)(q12q14), add(14)(q32)[4]/53-66, XX, +X, +X, +2, +3, +4, +5,del(6)(q12q14)×2, +6, +11, +12, +13, +18, +21, +22[cp5]/46,XX[3] | 0.35 | 0.42 | — | Maternal | ||
| 1754 | 49-55,XY, +X, +14, +18, +21, +21, inc[15] | 1.34 | 1.85 | 0.39 | Paternal | ||
| 1744 | 63-65,XX, +X, +1,t(2;14) (p11.2;q32), +del(2)(p11.2), +4, +5, +6, +6, +7, +8, +10, +10, +13, +add(14)(q32), +16, +18, +19, +20, +21, +21, +22, +mar1-4[cp6]/46,XX[4] | 0.29 | — | 0.37 | Maternal | ||
| 1710 | 52-60,XXX, +1, +6, +11, del(?13) (q13q31)t(?13;17)(q14;q11), +14, +17, +21[cp4]/46,XX[6] | 0.89 | 0.40 | — | Paternal | ||
| 1748 | 51-52,XX, +8, +16, +18, +20, +21, +21[cp4]/46,XX[6] | 0.62 | — | — | Maternal | ||
| 1722 | 56-57,XY, +X, +4, +6, +10, +14, +17, +21, +21, +22 [cp2]/46,XY[8] | — | — | 0.55 | Paternal | ||
. | . | Allele ratio* . | . | . | . | ||
|---|---|---|---|---|---|---|---|
| Case . | Karyotype . | D14S587 . | D14S617 . | D14S306 . | Origin +14 . | ||
| 1728 | 53-57, XX, +X, +X, dic(1;6) (p13;q25), +10, +11, +13, +14, +17, +18, +21, +22 [cp4]/46,XX[5] | 1.72 | — | — | Paternal | ||
| 1730 | 46,XX,del(6)(q12q14), add(14)(q32)[4]/53-66, XX, +X, +X, +2, +3, +4, +5,del(6)(q12q14)×2, +6, +11, +12, +13, +18, +21, +22[cp5]/46,XX[3] | 0.35 | 0.42 | — | Maternal | ||
| 1754 | 49-55,XY, +X, +14, +18, +21, +21, inc[15] | 1.34 | 1.85 | 0.39 | Paternal | ||
| 1744 | 63-65,XX, +X, +1,t(2;14) (p11.2;q32), +del(2)(p11.2), +4, +5, +6, +6, +7, +8, +10, +10, +13, +add(14)(q32), +16, +18, +19, +20, +21, +21, +22, +mar1-4[cp6]/46,XX[4] | 0.29 | — | 0.37 | Maternal | ||
| 1710 | 52-60,XXX, +1, +6, +11, del(?13) (q13q31)t(?13;17)(q14;q11), +14, +17, +21[cp4]/46,XX[6] | 0.89 | 0.40 | — | Paternal | ||
| 1748 | 51-52,XX, +8, +16, +18, +20, +21, +21[cp4]/46,XX[6] | 0.62 | — | — | Maternal | ||
| 1722 | 56-57,XY, +X, +4, +6, +10, +14, +17, +21, +21, +22 [cp2]/46,XY[8] | — | — | 0.55 | Paternal | ||
— indicates not done.
The allele ratio is the ratio of upper to lower bands, divided by the same ratio for the patient's normal (remission) DNA.