Table 2. Summary of BCR-ABL kinase... | American Society of Hematology

Table 2.

Summary of BCR-ABL kinase domain mutations

	IC₅₀ cell growth, μM imatinib	IC₅₀ BCR/ABL phosphorylation	Location
Wild-type	0.08	0.11	NA
M2371	0.17	0.25	Adjacent to P-loop
L248V	4.62	1.87	P-loop
D276G	2.97	0.60	C-helix
G321E	2.61	0.39	Imatinib binding site
Y353H	0.02	0.2	Adjacent to activation loop
E373G	2.78	0.71	Activation loop

	IC₅₀ cell growth, μM imatinib	IC₅₀ BCR/ABL phosphorylation	Location
Wild-type	0.08	0.11	NA
M2371	0.17	0.25	Adjacent to P-loop
L248V	4.62	1.87	P-loop
D276G	2.97	0.60	C-helix
G321E	2.61	0.39	Imatinib binding site
Y353H	0.02	0.2	Adjacent to activation loop
E373G	2.78	0.71	Activation loop

NA indicates not applicable.