Analysis of selected cytokines and coagulation factors in groups of mice (n = 5)
Cytokine/coagulation factor . | Uninfected . | Rat IgG, day 4 . | Anti-CD41, day 4 . | P, rat IgG vs α-CD41 . |
|---|---|---|---|---|
| IL-10, pg/mL | 135 ± 10 | 166 ± 26 | 386 ± 72 | .005 |
| IL-2, pg/mL | 1 ± 1 | 30 ± 8 | 5 ± 3 | .002 |
| IL-1α, pg/mL | 29 ± 4 | 53 ± 12 | 110 ± 27 | .03 |
| IFN-γ, pg/mL | 1 ± 1 | 25 ± 15 | 84 ± 18 | .01 |
| TNF-α, pg/mL | 0 ± 0 | 7 ± 7 | 62 ± 19 | .01 |
| IL-6, pg/mL | 0 ± 0 | 3 ± 3 | 33 ± 9 | .003 |
| Fibrinogen, μg/mL | 3156 ± 339 | 3363 ± 147 | 4560 ± 337 | .03 |
| fVII, ng/mL | 0.70 ± 0.05 | 0.60 ± 0.05 | 0.64 ± 0.06 | .6 |
| Tissue factor, ng/mL | 3.1 ± 0.06 | 3.3 ± 0.2 | 3.0 ± 0.2 | .5 |
| VWF, ng/mL | 444 ± 48 | 348 ± 152 | 344 ± 92 | .98 |
Cytokine/coagulation factor . | Uninfected . | Rat IgG, day 4 . | Anti-CD41, day 4 . | P, rat IgG vs α-CD41 . |
|---|---|---|---|---|
| IL-10, pg/mL | 135 ± 10 | 166 ± 26 | 386 ± 72 | .005 |
| IL-2, pg/mL | 1 ± 1 | 30 ± 8 | 5 ± 3 | .002 |
| IL-1α, pg/mL | 29 ± 4 | 53 ± 12 | 110 ± 27 | .03 |
| IFN-γ, pg/mL | 1 ± 1 | 25 ± 15 | 84 ± 18 | .01 |
| TNF-α, pg/mL | 0 ± 0 | 7 ± 7 | 62 ± 19 | .01 |
| IL-6, pg/mL | 0 ± 0 | 3 ± 3 | 33 ± 9 | .003 |
| Fibrinogen, μg/mL | 3156 ± 339 | 3363 ± 147 | 4560 ± 337 | .03 |
| fVII, ng/mL | 0.70 ± 0.05 | 0.60 ± 0.05 | 0.64 ± 0.06 | .6 |
| Tissue factor, ng/mL | 3.1 ± 0.06 | 3.3 ± 0.2 | 3.0 ± 0.2 | .5 |
| VWF, ng/mL | 444 ± 48 | 348 ± 152 | 344 ± 92 | .98 |
Plasma was obtained from uninfected mice or on day 4 of P berghei infection after injection with either anti-CD41 mAb or rat IgG on day 1 of P berghei infection. Mean plus or minus the standard error (SE) is reported. P indicates statistical significance by ANOVA for anti-CD41 mAb-treated group and rat IgG-injected group.